Effect of Maternal Restraint Stress on Fetal Development of ICR Mice
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概要
- 論文の詳細を見る
The present study was conducted to elucidate the susceptibility of embryos and fetuses at different gestational stages to the maternal stress in mice. Groups of pregnant ICR mice were subjected to daily 12-h restraint stress, taped in the supine position on a plastic board, on gestational days (GD) 1-4, 5-8, 9-12 and 13-16, respectively. Caesarean sections were performed on gestational day 18, and the fetuses were weighed and examined for morphological defects. During the daily restraint for 4 days, the maternal body weights markedly decreased. Although the body weights recovered gradually after termination of the stress, the recovery was not full until the final stage of pregnancy. Interestingly, restraint stress caused growth retardation of the fetuses, leading to a significant decrease in their body weights, and increased early and late resorptions of embryos and fetuses according to the stress periods. Although the preceding (GD1-4) and concurrent (GD5-8) stresses did not affect embryonic implantation, restraint stress on GD9-12 caused cleft palate. Whereas vertebral abnormalities, mainly bipartite ossification, were observed only in animals stressed on GD5-8, abnormalities of sternebrae, exhibiting asymmetric or bipartite ossification, were enhanced by the stress at all of the gestational stages. On the other hand, the incidence of other malformations including renal malposition and costal abnormalities was not increased by stress at any of the 4 stages. Taken together, the results suggest that intensive restraint stress influences the maternal body weight resulting in growth retardation and increased mortality of embryos and fetuses, in addition to gestational stage-specific ventricular dilatation, cleft palate and sternal abnormalities.
- 社団法人 日本実験動物学会の論文
- 2008-01-01
著者
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Kim Jong-choon
Coll. Of Veterinary Medicine Chonnam National Univ.
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HWANG Seock-Yeon
Department of Laboratory of Clinical Science, Juseong College
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KIM Yun-Bae
College of Veterinary Medicine, Chungbuk National University
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Shin Sunhee
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Park Dongsun
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Kim Jong-Choon
College of Veterinary Medicine, Chonnam National University
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S‐y
Chungbuk National Univ. Cheungju Kor
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Nam Sang-yoon
韓国
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Nam Sang-yoon
東京大学 大学院
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Kang J‐k
Coll. Of Veterinary Medicine Chonnam National Univ.
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Kim Yun-bae
Dep. Of Medicine Univ. Of British Columbia Hospital
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Jeon Jeong
韓国
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Kim Sunghyun
Coll. Of Veterinary Medicine And Res. Inst. Of Veterinary Medicine Chungbuk National Univ.
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Hwang Seock-yeon
Dep. Of Lab. Of Clinical Sci. Juseong Coll.
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Jang Ja
韓国
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Kim Y
Department Of Public Health College Of Natural Sciences Keimyung University
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Kim Yun-bae
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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JANG Ja
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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CHOI Byong-il
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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JEON Jeong
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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Jang Ja
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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KANG Jong-Koo
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Nam Sang-yoon
College Of Veterinary Medicine Konkuk University
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Nam Sang
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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LEE Yea
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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BYUN Sang
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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NAHM Sang-Seop
College of Veterinary Medicine, Konkuk University
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Lee Yea
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Kim Jong-choon
College Of Veterinary Medicine Chonnam National University
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Hwang Seock-yeon
Department Of Clinical Laboratory Science Juseong College
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Cho Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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KIM Yun-Bae
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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PARK Dongsun
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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Shin Sunhee
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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