Protective Effects of Sanjoinine A against N-Methyl-D-aspartate-Induced Seizure(Pharmacology)
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概要
- 論文の詳細を見る
Sanjoinine A is a component of the alkaloid fraction of Zizyphi Spinosi Semen. This experiment was performed to investigate whether sanjoinine A acts as an anticonvulsive in the N-methyl-D-aspartate (NMDA)-induced experimental seizure model. We also examined whether it protects against seizure-form electroencephalogram (EEG) alterations induced by NMDA in vivo and/or cell killing due to NMDA in cultured cerebellar granule cells. Administration of sanjoinine A increased the survival rate and the latency of seizure onset, and decreased the seizure scores and the weight-loss induced by NMDA in mice, in a dose-dependent manner, In addition, sanjoinine A blocked seizure-form EEG alterations induced by NMDA and inhibited NMDA-induced cell killing in cultured rat cerebellar granule cells, measured by both the trypan blue exclusion test and the 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Moreover, sanjoinine A inhibited the elevation of intracellular calcium influx induced by NMDA, which was measured using a fluorescent dye, Furo 3-AM. It is suggested that sanjoinine A protects against NMDA-induced seizures by inhibiting intracellular calcium influx.
- 社団法人日本薬学会の論文
- 2008-09-01
著者
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KIM Yun-Bae
College of Veterinary Medicine, Chungbuk National University
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Oh Ki-wan
College Of Pharmacy Chunghuk National University
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Nam Sang-yoon
College Of Veterinary Medicine Chungbuk National University
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Oh Ki-wan
College Of Pharmacy Chungbuk National University
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MA Yuan
Research Institute of Veterinary Medicine, Chungbuk National University
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YUN Sung-Ryul
College of Pharmacy, Chunghuk National University
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HONG Jin-Tae
College of Pharmacy, Chunghuk National University
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KIM Younghoon
College of Oriental Medicine, Wonkwang University
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CHOI Heesuk
College of Oriental Medicine, Wonkwang University
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LEE Kinam
College of Oriental Medicine, Wonkwang University
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Lee Kinam
College Of Oriental Medicine Wonkwang University
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Kim Younghoon
College Of Oriental Medicine Wonkwang University
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Kim Yun-bae
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Kim Yun-bae
College Of Veterinary Medicine Chungbuk National University
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Hong Jin
Coll. Of Pharmacy Chungbuk National Univ. Kor
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Hong Jin-tae
College Of Pharmacy Chunghuk National University
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Hwang Ji-hye
College Of Pharmacy Cbitrc Chungbuk National University
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Yun Sung-ryul
College Of Pharmacy Chunghuk National University
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Ma Yuan
Research Institute Of Veterinary Medicine Chungbuk National University
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Choi Heesuk
College Of Oriental Medicine Wonkwang University
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Hong Jin
College Of Pharmacy And Cbitrc Chungbuk National University
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Nam Sang-yoon
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Hong Jin-tae
College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers
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KIM Yun-Bae
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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Hong Jin-Tae
College of Pharmacy and Medical Research Center, Chungbuk National University
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