Expression Pattern of Sulfated Glycoprotein-2 (SGP-2) mRNA in Rat Testes Exposed to Endocrine Disruptors
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概要
- 論文の詳細を見る
Sulfated glycoprotein-2 (SGP-2) is secreted in Sertoli cells and epididymal epithelial cells and plays important roles in the regulation of spermatogenesis and sperm maturation. To investigate whether endocrine disruptors affect spermatogenesis through an SGP-2-dependent mechanism, daily oral doses of testosterone (50, 200 and 1,000 μg/kg), flutamide (1, 5 and 25 mg/kg), ketoconazole (0.2, 1, 5 and 25 mg/kg), diethylhexylphthalate (10, 50 and 250 mg/kg), nonylphenol (10, 50, 100 and 250 mg/kg), octylphenol (10, 50 and 250 mg/kg), diethylstilbesterol (10, 20 and 40 μg/kg) or corn oil (control) were administered to 5 week-old, male Sprague-Dawley rats for 3 weeks. Following treatment with these endocrine disruptors, testicular expression of SGP-2 mRNA was analyzed using reverse transcription-polymerase chain reaction. Compared with the control, the lowest dose of testosterone (50 μg/kg/day) significantly increased expression of SGP-2 mRNA, whereas 200 and 1,000 μg/kg/day testosterone significantly decreased expression (p<0.05). Flutamide, ketoconazole, diethylhexylphthalate, nonylphenol, octylphenol and diethylstilbesterol significantly decreased SGP-2 mRNA expression in testes at all doses studied, with the exception of 1 mg/kg/day flutamide (p<0.05). These results suggest that endocrine disruptors might decrease spermatogenesis in testes by decreasing expression of SGP-2 mRNA.
- 日本繁殖生物学会の論文
- 2007-10-01
著者
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Jung E‐y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
Seoul National Univ. Seoul Kor
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Yun Y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S‐y
Chungbuk National Univ. Cheungju Kor
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Nam Sang-yoon
韓国
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Nam Sang-yoon
東京大学 大学院
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Lee Se-ra
韓国
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Kim Yun-bae
Dep. Of Medicine Univ. Of British Columbia Hospital
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Nam Sang-yoon
College Of Veterinary Medicine Chungbuk National University
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Lee Beom
College Of Veterinary Medicine Chungbuk National University
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Kim Y
Department Of Public Health College Of Natural Sciences Keimyung University
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YUN Young
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Baek I‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Lee Beom
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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LEE Se-Ra
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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YON Jung-Min
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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BAEK In-Jeoung
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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KWAK Dong
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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CHO Young
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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JIN Yan
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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LEE Jeung
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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NAHM Sang-Soep
College of Veterinary Medicine, Konkuk University
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CHOO Young-Kug
Department of Biological Science, College of Natural Sciences, Wonkwang University
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Lee J‐y
College Of Medicine Hallym University
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Nam Sang-yoon
College Of Veterinary Medicine Konkuk University
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Nam Sang
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Se-ra
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yon J‐m
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Kwak Dong
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Natural Sciences Department Of Biological Sciences Pusan National University
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Lee B
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Nam Sang-yoon
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Baek In-jeoung
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Choo Young-kug
Department Of Biological Science College Of Natural Sciences Institute Of Biotechnology Wonkwang Uni
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Cho Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yon Jung-Min
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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NAHM Sang-Soep
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
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