ゲニステインとエストラジオールが生殖器の発達に及ぼす影響 : 大豆ベースの餌によって飼育した母マウスから生まれたオスの性成熟への影響(毒性学)
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概要
- 論文の詳細を見る
大豆由来イソフラボンであるゲニステインは栄養補助食品としてその効果が認められているが,同時にエストロゲン様作用が雄性生殖器の発達に及ぼす影響も懸念されている.そこで,本研究では,この点を明らかにする為に,妊娠および授乳期に大豆ベースの餌を食べさせた母親から生まれた21日齢のマウスに,ゲニステイン(2.5mg/kg/day)およびエストラジオール(7.5μg/kg/day)を5週間投与した.実験期間中,マウスはカゼインベースのAIN-76で飼育を行った.ゲニステイン投与とコントロール群(コーンオイル投与)との間に精子数や精子運動能に関して違いは見られなかった.エストラジオール投与群では前立腺重量や精巣上体精子数が,コントロール群に比べて顕著に減少していた.セレン依存性ペルオキシダーゼ・スーパーファミリーのひとつであるphospholipid hydroperoxide glutathione peroxidase (PHGPx)はゲニステインおよびエストラジオール投与群で,コントロールに比べて有意に増加していた.エストラジオール投与は精子変性やアポトーシス増加,精巣上体の変性や前立腺のhyperplasiaを引き起こしていたが,ゲニステイン投与マウスでは,これらに関し異常は見られなかった.従って,成長期のゲニステインの日常的な摂取は,生殖器の発達や機能には影響を与えないことが示唆された.
- 2004-11-25
著者
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Kim Jong-choon
Coll. Of Veterinary Medicine Chonnam National Univ.
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Kim K
Yong-in Univ. Yongin‐si Kor
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Jung E‐y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
Seoul National Univ. Seoul Kor
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Yun Y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Yun Young
Department Of Electrical Engineering Faculty Of Engineering Science Osaka University
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S‐y
Chungbuk National Univ. Cheungju Kor
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Nam Sang-yoon
韓国
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Nam Sang-yoon
東京大学 大学院
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Lee Y
College Of Veterinary Medicine Seoul National University
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Lee Yoon-bok
韓国
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Lee Yb
Central Research Institute Dr. Chung's Food Co. Ltd.
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Sohn Heon-soo
韓国
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Sohn Hs
Central Research Institute Dr. Chung's Food Co. Ltd.
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Kang J‐k
Coll. Of Veterinary Medicine Chonnam National Univ.
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Kim K‐s
Department Of Food And Nutrition Yong-in University
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Kim Yun-bae
Dep. Of Medicine Univ. Of British Columbia Hospital
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Kim Y
Department Of Public Health College Of Natural Sciences Keimyung University
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Baek I‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Yun Young
Department Of Earth And Planetary Sciences School Of Science Tokyo Institute Of Technology
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LEE Yoon-Bok
Central Research Institute, Dr. Chung's Food Co. Ltd.
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SOHN Heon-Soo
Central Research Institute, Dr. Chung's Food Co. Ltd.
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Lee J‐y
College Of Medicine Hallym University
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JUNG Eun-Yong
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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LEE Beom-Jun
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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KANG Jong-Koo
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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BAEK In-Jeoung
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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YON Jung
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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LEE Jae-Yong
Department of Biochemistry, College of Medicine, Hallym University
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KIM Kang-Sung
Department of Food Science and Nutrition, Yong-in University
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YU Wook-Joon
Satefy Research Center
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DO Jae
Gyeongbuk Veterinary Service Laboratory
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NAM Sang-Yoon
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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Nam Sang-yoon
College Of Veterinary Medicine Konkuk University
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Nam Sang
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Sohn H‐s
Central Research Institute Dr. Chung's Food Co. Ltd.
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Lee Y‐b
Central Research Institute Dr. Chung's Food Co. Ltd.
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Yu Wook-joon
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yon J‐m
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Yu Wook
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Cho Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Yoon-Bok
Central Research Institute, Dr. Chung's Food Co., Ltd.
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