Flavan-3-ols Having a γ-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro

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概要

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• Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(-)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(-)-epicatechin (2), as well as five known compounds, (-)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products (AGEs). Of these, compounds 1-5 exhibited significant inhibitory activity against AGEs formation with IC_<50> values ranging from 10.1 to 125.2μM.

• 社団法人日本薬学会の論文
• 2009-04-01

著者

• Kim Young

  Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicin

• KIM Jin

  Departments of Surgery, Seoul National University College of Medicine

• Kim Young

  Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology

• Lee Yun

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• JANG Dae

  Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• LEE Ga

  Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• LEE Yun

  Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• SUN Hang

  Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Science

• KIM Dong-Hee

  College of Oriental Medicine, Daejeon University

• Kim Ji-yeon

  韓国

• Kim J‐y

  Yeungnam Univ. Taegu Kor

• Lee Ga

  Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine

• Lee Y

  Professional Graduate School Of Oriental Medicine And Medicinal Resources Research Institute (merri)

• Kim Jin

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Kim Young

  Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine

• Sun Hang

  Laboratory Of Biodiversity And Biogeography Kunming Institute Of Botany Chinese Academy Of Sciences

• Jang Dae

  Diabetes Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea Inst. Of Orient

• Jang Dae

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Jang Dae

  Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine

• Kim Jong-bin

  Coll. Of Pharmacy Kyung-hee Univ.

• Kim Jong-pyung

  Laboratory Of Antioxidants Korea Research Institute Of Bioscience And Biotechnology

• Kim Dong-hee

  College Of Oriental Medicine Daejeon University

• Kim Joo-hwan

  Dep. Of Life Sci. Daejeon Univ.

• Kim Young

  Department Of Agricultural Chemistry The University Of Tokyo

• Lee Yun

  Department Of Applied Chemistry Saga University

• Kim Jin

  Diabetic Complications Res. Center Div. Of Traditional Korean Medicine Integrated Res. Korea Inst. O

• Kim Jin

  Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar

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