Relationship Between Global Cytosolic Ca^<2+> Concentration and Ca^<2+> activated K^+ Current in Rabbit Cerebral Arterial Myocyte
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概要
- 論文の詳細を見る
In smooth muscle cells, the sarcoplasmic reticulum (SR) has been identified as the primary storage site for intracellular Ca^<2+>. The peripheral SR is in close proximity with plasma membrane to make a narrow subsarcoleummal space. In this study, we investigated the regulation of subsarcolemmal [Ca^<2+>] ( [Ca^<2+>]_<S1>) and global cytosolic [Ca^<2+>] ( [Ca^<2+>]_C) of rabbit arterial smooth muscle using whole-cell patch clamp technique and microspectrofluorimetry. The Ca^<2+>-activated K^+ current (I_<K(Ca)>) and the ratio of fura-2 fluorescence (R_<340/380>) were considered to reflect the [Ca^<2+>]_<S1> and [Ca^<2+>]_C, respectively. At a holding potential of 0 mV, extracellular application of 10 mM caffeine, a well-known Ca^<2+>-releasing agent, induced transient increase of I_<K(Ca)>) and R_<340/380> (I_<K(Ca)>-transient and R_<340/380>-transient, respectively). The increase and decay of I_<K(Ca)>l-transient was faster than R_<340/380>-transient. By repetitive application of caffeine, when the refilling state of SR was supposed to be lower than the control condition, I_<K(Ca)>-transient and R_<340/380>-transient were suppressed to different levels; e.g. the second application 20 sec after the first could induce smaller I_<K(Ca)>-transient than R_<340/380>-transient. Dissociation of I_<K(Ca)>-transient and R_<340/380>-transient was removed by sufficient (>3 min) washout of caffeine. Recovery from the dissociation was also dependent upon the membrane potential; faster recovery was observed at negative (-40 mV) holding potential than at depolarized (0 mV) condition. Dissociation of I_<K(Ca)> from [Ca^<2+>]_C was also partially prevented by perfusion with Na^+-free (replaced by NMDG^+) extracellular solution. These results suggest that, 1) there is prominent spatial inhomogeneity of [Ca^<2+>] in cerebral arterial myocyte, 2) [Ca^<2+>]_<S1> is preferentially affected by the interference from nearby plasmalemmal Ca^<2+> regulation mechanism which is partly dependent upon extracellular Na^+.
- 日本平滑筋学会の論文
著者
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PARK Sung
Department of Material Science & Engineering, Gwangju Institute of Science and Technology
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Kim Sung
Department of Bioengineering and Technology, College of Engineering, Kangwon National University
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Kim Ki
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res
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So Insuk
Department of Physiology, Seoul National University College of Medicine
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Kim Ki
韓国
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Kim K
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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Kim Y
Seoul National Univ. Seoul Kor
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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So Insuk
Department Of Physiology Seoul National University College Of Medicine
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So Insuk
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Kim Ki
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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Choi Jae
Department Of Electronics Engineering University Of Incheon
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Choi Jae
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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Kim Sung
Department Of Physiology Seoul National University College Of Medicine
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Choi Jae
Department Of Physiology & Biophysics Seoul National University College Of Medicine.
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Kim Sung
Department Of Anatomy
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Kim Young
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Kim S
Department Of Physiology Seoul National University College Of Medicine
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Park S
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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SUH Suk
Department of Physiology, College of Medicine, Ewha Womans' University
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AHN Joong
Department of Radiology, Samsung Medical Center, College of Medicine, SungKyunKwan University.
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Suh Suk
Department Of Physiology College Of Medicine Ewha Womans' University
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Ahn Joong
Department Of Radiology Samsung Medical Center College Of Medicine Sungkyunkwan University.
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Ahn Joong
Department Of Atmospheric Sciences Pusan National University
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Kim Young
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Park Sung
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Kim Sung
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea
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Kim Sung
Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea
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