No Association of Pro12Ala Polymorphism of PPAR-γ Gene With Coronary Artery Disease in Korean Subjects
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概要
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Background Peroxisome proliferator-activated receptor(PPAR)-γ, a member of the nuclear hormone receptor family, which is involved in the differentiation of adipose tissue, is reported to be associated with the pathogenesis of type 2 diabetes mellitus, insulin resistance and atherosclerosis. Whether the prevalence of coronary artery disease(CAD) is associated with Pro12Ala polymorphism in exon B of PPAR-γ was investigated in Korean adults. Methods and Results The study was conducted in 267 subjects(158 males, 109 females, mean age 58 years) who underwent coronary angiography because of chest pain. Cardiovascular risk factors, such as blood pressure, body mass index(BMI), fasting blood sugar and serum lipid profiles, were assessed in all subjects, who were divided into 4 groups according to the number of stenosed coronary arteries: normal, 1-vessel, 2-vessel and 3-vessel disease. Genotyping of Pro 12Ala polymorphism was done with real-time polymerase chain reaction. Allelic frequency for proline was 0.955 and 0.045 for alanine, which was in Hardy-Weinberg equilibrium(p= 0.74). One hundred and seventeen subjects(43.8%) had normal coronary arteries, 88(33%) had 1-vessel disease, 39(14.6%) had 2-vessel disease and 23(8.6%) had 3-vessel disease. When the cardiovascular risk factors were compared among the 4 groups, there were no meaningful differences except for age and FBG levels, which were significant even after adjustment for age and BMI. There were no significant differences in the prevalence or severity of CAD according to the different genotypes of Pro 12Ala, and in logistic regression analysis Pro 12Ala polymorphism was not a predictor for CAD. Conclusions There was no significant association between Pro 12Ala polymorphism in exon B of PPAR-γ and prevalence or severity of CAD in Korean adults. Further studies on the correlation between Pro 12Ala polymorphism and CAD should be carried out in a larger Korean population in the future.
- 社団法人日本循環器学会の論文
- 2007-02-20
著者
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PARK Sung
Department of Material Science & Engineering, Gwangju Institute of Science and Technology
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KANG JIN
Department of Pediatrics, The Catholic University of Korea
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KIM Sun
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University Scho
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Kim Bum
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Kim Sun
Department Of Chemical Engineering Sogang University
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PARK Jung
Department of East-West Medicine, Graduate School, Kyung Hee University
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Park Jung
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Sung Ki
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici
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Lee Man
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici
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Rhee Eun
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kwon Chang
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Lee Won
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kirn Se
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Jung Chan
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kirn Byung
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kirn Bum
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Oh Ki
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kirn Se
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Lee Man
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Kim Byung
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Rhee Eun
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Rhee Eun
Department Of Computer Science Taejon National University Of Technology
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Kang Jin
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Jung Chan
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Sung Ki
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Lee Won
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Kang Jin
Department Of Biomedical Laboratory Science Namseoul Univeristy
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Lee Man
Department Of Advanced Materials Science & Engineering Mokpo National University
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Oh Ki
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Jung Chan
Department Of Chemical Engineering Hanyang University
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Kwon Chang
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Oh Ki
Department Of Diagnostic Radiology And Radiology Research Institute College Of Medicine Yonsei Unive
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Kim Sun
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Lee Won
Department Of Agricultural And Biological Engineering University Of Florida
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Park Jung
Department Of Chemistry Gyeongsang National University
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Park Sung
Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Park Sung
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Kang Jin
Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School
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Park Jung
Department Electrical Engineering Busan National University
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Kwon Chang
Department Of Cardiology Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine
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Sung Ki
Department Of Cardiology Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine
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Kang Jin
Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine
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Kim Byung
Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine
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LEE Man
Department of Advanced Material Science & Engineering, Mokpo National University
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