1,3-Selenazol-4-one Derivatives Inhibit Inducible Nitric Oxide-Mediated Nitric Oxide Production in Lipopolysaccharide-Induced BV-2 Cells (Pharmacology)
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概要
- 論文の詳細を見る
Activated microglia extensively produce nitric oxide (NO) by inducing expression of inducible NO synthase (iNOS). NO plays a deleterious role in brain inflammation and neuronal death. In the present study, we investigated the effects of l,3-selenazol-4-one derivatives (Sz-A, B, C, D and E) on NO production and iNOS expression in lipopolysaccharide (LPS)-induced BV-2 cells, a murine microglia cell line. Among these compounds, Sz-B and C remarkably inhibited LPS-induced NO production relative to that of Sz-A, D, and E at 5 μM in BV-2 cells. Sz-B and C dose-dependently inhibited NO production at 1, 5, and 10μM without toxicity to BV-2 cells. Sz-B and C also dose-dependently suppressed iNOS expression at the same concentrations in LPS-induced BV-2 cells. This result suggests that Sz-B and C inhibit iNOS-mediated NO production in LPS-induced BV-2 cells. Structurally, Sz-B and C bear an ethyl or methyl group at the 5 positions of the 4-selenazolone skeletons, which could play an important role in inhibiting iNOS-mediated NO production.
- 社団法人日本薬学会の論文
- 2003-12-01
著者
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Koike Minako
岐阜県国際バイオ研究所
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Kim Sun
Department Of Chemical Engineering Sogang University
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Yeo Joo-hong
Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology
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Kim Sun
Graduate School Of East-west Medicine Kyung Hee Univ.
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim Sung-soo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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KIM Jeong
Department of Information Electronics Engineering, Ewha Womans University
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ISHIHARA Hideharu
Department of Chemistry, Faculty of Engineering, Gifu University
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LEE Kunho
Graduate School of East-West Medical Science, Kyung Hee University
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PARK Young-Joon
Department of Physical Pharmacy, College of Pharmacy, Seoul National University
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KOKETSU Mamoru
Department of Chemistry, Faculty of Engineering, Gifu University
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LEE Kwang-Gill
Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology
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KIM Chong-Kook
Department of Physical Pharmacy, College of Pharmacy, Seoul National University
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Lee Kun
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Jeong
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Lee Kang
Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology
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Kim Jeongmin
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Jeong
Department Of Anatomy Wonkwang University School Of Medicine
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Park Young-joon
Department Of Physical Pharmacy College Of Pharmacy Seoul National University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Chong-kook
Department Of Physical Pharmacy College Of Pharmacy Seoul National University
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Koketsu Mamoru
Department Of Chemistry Faculty Of Engineering Gifu University
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Ishihara H
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Koketsu Mamoru
Research Center Suntory Limited
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Ishihara Hideharu
Department Of Chemistry Faculty Of Engineering Gifu University
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Ishihara Hideharu
Dep. Of Chemistry Fac. Of Engineering Gifu Univ.
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Mamoru Koketsu
Research Center Suntory Limited
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