Potent Inhibitory Effects of N-Aryl S-Alkylthiocarbamate Derivatives on the Dopa Oxidase Activity of Mushroom Tyrosinase

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概要

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• This study reports the potent inhibitory effect of N-aryl S-alkylthiocarbamate derivatives on mushroom tyrosinase (MT) activity. N-Aryl S-alkylthiocarbamate derivatives were found to exhibit a potent inhibitory effect on the dopa (3,4-dihydroxyphenylalanine) oxidase activity of mushroom tyrosinase. Most of the N-aryl S-alkyl-thiocarbamate derivatives (compounds from A to J) exhibited higher inhibitory effects than kojic acid (IC_<50>=318μm), a well known tyrosinase inhibitor. Tyrosinase was the most inhibited by S-phenetyl N-phenylthiocarbamate (compound E, IC_<50>=7.25μM), and this inhibition was 44 times stronger than that of kojic acid. Compound E exhibited 95.0% of inhibition at 100μm. A kinetic study of MT inhibition by compound E using the Lineweaver-Burk plots analysis was performed. And the kinetics profiles observed suggest that compound E competitively inhibits MT.

• 2005-07-01

著者

• KIM Sun

  Graduate School of East-West Medicine, Kyung Hee University

• Koike Minako

  岐阜県国際バイオ研究所

• Kim Sun

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Choi Sang

  Korea Res. Inst. Of Chemical Technol. Daejeon Kor

• Choi Sang

  韓国

• Kim Sung-soo

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Kim Sung-soo

  Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno

• Kim S

  Graduate School Of East-west Medicine Kyung Hee Univ.

• KOKETSU Mamoru

  Division of Instrumental Analysis, Life Science Research Center, Gifu University

• ISHIHARA Hideharu

  Department of Chemistry, Faculty of Engineering, Gifu University

• LEE Kun

  Graduate School of East-West Medical Science, Kyung Hee University

• LEE Kang

  Graduate School of East-West Medical Science, Kyung Hee University

• LEE Pyeongjae

  Rural Development Administration, National Institute of Agricultural Science and Technology

• LEE Kunho

  Graduate School of East-West Medical Science, Kyung Hee University

• Lee Kun

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Lee Kang

  Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology

• Kim S

  Graduate School Of East-west Medical Science Kyung Hee University

• Lee Pyeongjae

  Department Of Natural Medicine Resources Semyung University

• Lee Pyeongjae

  Department Of Sericulture And Entomology National Institute Of Agricultural Science & Technology

• Koketsu Mamoru

  Division Of Instrumental Analysis Life Science Research Center Gifu University

• Choi S

  Kyung Hee Univ. Seoul Kor

• Ishihara H

  Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive

• Choi Sang

  Korea Food Res. Inst.

• Koketsu Mamoru

  Research Center Suntory Limited

• Kim Sun

  Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Ishihara Hideharu

  Department Of Chemistry Faculty Of Engineering Gifu University

• Ishihara Hideharu

  Dep. Of Chemistry Fac. Of Engineering Gifu Univ.

• Mamoru Koketsu

  Research Center Suntory Limited

• Kim Sun

  Graduate School Of East-west Medical Science

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