Superoxide Anion-Scavenging Effect of 2-Amino-1,3-selenazoles

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概要

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• We investigated the superoxide anion scavenging effects of thirteen 2-amino-1, 3-selenazoles using a highly sensitive quantitative chemiluminescence method. At 166μM, the 2-amino-1, 3-selenazoles scavenged in the range of 14.3 to 96.7% of O^-_2. 2-Piperidino-1, 3-selenazole and 4-phenyl-2-piperidino-1, 3-selenazole exhibited the strongest superoxide anion-scavenging activity among the 2-amino-1, 3-selenazoles. The 50% inhibitory concentrations (IC_<50>) of 2-piperidino-1, 3-selenazole and 4-phenyl-2-piperidino-1, 3-selenazole were determined to be 4.03μM and 92.6μM, respectively. Thus, these compounds acted in vitro as effective O^-_2 scavengers.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• KIMURA Hirokazu

  Gunma Prefectural Institute of Public Health and Environmental Sciences

• KOKETSU Mamoru

  Division of Instrumental Analysis, Life Science Research Center, Gifu University

• ISHIHARA Hideharu

  Department of Chemistry, Faculty of Engineering, Gifu University

• Fukumoto Ryohei

  Gunma Industrial Technology Center

• Koketsu Mamoru

  Division Of Instrumental Analysis Life Science Research Center Gifu University

• SEKIGUCHI Akihiro

  Gunma Industrial Technology Center

• NISHINA Atsuyoshi

  Gunma Industrial Technology Center

• KANOH Koichi

  Department of Chemistry, Faculty of Engineering, Gifu University

• Ishihara H

  Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive

• Koketsu Mamoru

  Research Center Suntory Limited

• Ishihara Hideharu

  Department Of Chemistry Faculty Of Engineering Gifu University

• Ishihara Hideharu

  Dep. Of Chemistry Fac. Of Engineering Gifu Univ.

• Mamoru Koketsu

  Research Center Suntory Limited

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