Bis-(2-amino-5-selenazoyl) Ketone as a Superoxide Anion-Scavenger(Medicinal Chemistry)

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概要

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• We investigated the superoxide anion scavenging effects of 2-amino-1,3-selenazoles and bis-(2-amino-5-selenazoyl) ketones using a highly sensitive quantitative chemiluminescence method. At 166μM, the 2-amino-1,3-selenazoles and bis-(2-amino-5-selenazoyl) ketones scavenged in the range of 10.0 to 80.0% of O^-_2. Bis[2-dimethyl-amino-5-(1,3-selenazolyl)] ketone exhibited the strongest superoxide anion-scavenging activity among the six kinds of 2-amino-1,3-selenazoles and three kinds of bis-(2-amino-5-selenazoyl) ketones. The 50% inhibitory concentration (IC_<50>) of bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone was determined to be 37.1μM. Thus, bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone acted in vitro as effective and potentially useful O^-_2 scavenger.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• KIMURA Hirokazu

  Gunma Prefectural Institute of Public Health and Environmental Sciences

• KOKETSU Mamoru

  Division of Instrumental Analysis, Life Science Research Center, Gifu University

• ISHIHARA Hideharu

  Department of Chemistry, Faculty of Engineering, Gifu University

• Fukumoto Ryohei

  Gunma Industrial Technology Center

• Koketsu Mamoru

  Division Of Instrumental Analysis Life Science Research Center Gifu University

• SEKIGUCHI Akihiro

  Gunma Industrial Technology Center

• NISHINA Atsuyoshi

  Gunma Industrial Technology Center

• FUKUMOTO Ryo-hei

  Gunma Industrial Technology Center

• KOGAMI Masakazu

  Department of Chemistry, Faculty of Engineering, Gifu University

• Kogami Masakazu

  Department Of Chemistry Faculty Of Engineering Gifu University

• Ishihara H

  Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive

• Koketsu Mamoru

  Research Center Suntory Limited

• Ishihara Hideharu

  Department Of Chemistry Faculty Of Engineering Gifu University

• Ishihara Hideharu

  Dep. Of Chemistry Fac. Of Engineering Gifu Univ.

• Mamoru Koketsu

  Research Center Suntory Limited

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