Synthesis and Application of Neoglycolipids for Liposome Modification
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概要
- 論文の詳細を見る
We synthesized various glycolipid derivatives and examined the in vivo behaviors of liposomes modified with these movel glycolipid derivatives. Gal-t-pas (1,{8-(2-hexadecyloctadecanoylamino)-3,6-dioxaoctyl}-β-D-galactoside), Lac-t-psa (3,8-(2-hexadecyloctadecanoylamino)-3,6-dioxaoctyl β-D-lactoside) and GalNAc-t-psa (4,8-(2-hexadecyloctadecanoylamino)-3,6-dioxaoctyl 2-acetamido-β-D-galactopyranoside) modified liposomes were recognized by the liver. Lac-t-psa (3) modified liposome was accumulated to the highest degree, followed by GalNAc-t-psa (4) modified liposome and then Gal-t-psa (1) modified liposome. The intrahepatic distributions of Gal-t-psa (1), GalNAc-t-psa (4), Glc-t-psa (2,8-(2-hexadecyloctadecanoylamido)-3,6-dioxaoctylβ-D-glucopyranoside) and Lac-t-psa (3) modified liposomes were investigated. GalNAc-t-psa (4) and Lac-t-psa (3) modified liposome were accumulated to greater extents than Gal-t-psa (1) modified liposome in hepatic parenchymal cells. The intrahepatic distribution of these liposomes showed that Lac-t-psa (3) and GalNAc-t-psa (4) were preferable to Gal-t-psa (1) for the selective delivery of liposomes to hepatic parenchymal cells.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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村橋 直一
東京理科大学生命科学研究所内 (株)ディ・ディ・エス研究所
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Sasaki A
Tsukuba Research Laboratories Eisai Co. Ltd.
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MURAHASHI Naokazu
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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ISHIHARA Hiroshi
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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SAKAGAMI Masahiro
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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SASAKI Atsushi
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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Ishihara H
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Sakagami M
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Murahashi N
Eisai Co. Ltd. Gifu Jpn
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Murahashi Naokazu
Drug Delivery System Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Sasaki Atsushi
Drug Delivery System Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Ishihara Hideharu
Dep. Of Chemistry Fac. Of Engineering Gifu Univ.
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