Sntheses and Evaluation of Biantennary Oligosaccharide Ligands Mimicking Sialyl Lewis X
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概要
- 論文の詳細を見る
Sialyl Lewis X (1) is known to be a ligand of the cell adhesion molecule E-selectin. We have synthesized several biantennary glycoside-terminated ligands mimicking sialyl Lewis X (1), and evaluated their binding activity to E-selectin using HL-60 cells expressing sialyl Lewis X epitope and human umbilical vein endothelial cells (HU-VECs). These compounds were found to possess moderate binding activities to E-selectin. Among them, di-fucoside analogn (8) which has no sialic acid carboxylate group was more active than 2,which had both the sialyl-galactose residue and the fucose residue (IC_<50>, 8 : 4.7 mM, 2 : 11.7 mM). Furthemore, in the rat pleuritic model in vivo induced by carrageenin, 8 was found to reduce neutrophil infiltration at inflammatory lesions.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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山田 治民
(株) ディ・ディ・エス研究所
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Yamada H
Yamada Apiculture Center Inc.
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Yamada H
School Of Science And Technology Kwansei Gakuin University
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SAKAGAMI Masahiro
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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YAMADA Harutami
Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive
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HAMANA Hiroshi
Drug Delivery Systme Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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Hamana H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hamana H
Discovery Research Laboratories Shionogi & Co. Ltd.
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Hamana Hiroshi
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Yamada Harutami
Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.
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Yamada Harutami
Drug Delivery System Institute Ltd. Bldg. Of Research Institute For Biosciences The Science Universi
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Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Sakagami M
Shionogi Research Laboratories Shionogi & Co. Ltd.
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HORIE Kazutoshi
Drug Delivery System Institute, Ltd.,
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HIGASHI Kunio
Drug Delivery System Institute, Ltd.
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Hamana Hiroshi
Dep. Of Pharmaceutical Chemistry Chiba Inst. Of Sci.
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