Preventive Effect of Co-administration of Water Containing Magnesium Ion on Indomethacin Induced Lesions of Gastric Mucosa in Adjuvant-Induced Arthritis Rat(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
It is well known that nonsteroidal anti-inflammatory drugs (NSAIDs) have significant side effects, such as gastroenteropathy, and that rheumatoid arthritis patients taking NSAIDs are more susceptible to NSAIDs-induced gastric lesions as compared with patients with other diseases. We demonstrate the preventive effect of the co-administration of bittern water (BW, nigari-sui in Japanese), which enables the effective intake of Mg^<2+>, on the ulcerogenic response to indomethacin in adjuvant-induced arthritis (AA) rats. Four kinds of BW with different Mg^<2+> contents; ranging from 10-200mg/l Mg^<2+> (BW-10, 25, 50, 200) were used in this study. Arthritis was induced by the injection of 50μl of a suspension of 10mg/ml heat-killed butyricum (Mycobacterium butyricum) in Bayol F oil into the plantar region of the right hind foot and tail of rats. Oral administration of indomethacin (40mg/kg) caused hemorrhagic lesions in the gastric mucosa of AA rats at 14d after adjuvant injection, and the lesion score of AA rats administered indomethacin was significantly higher than that of normal rats administered indomethacin. The expression of the mRNA for inducible nitric oxide synthase (iNOS) mRNA expression and the production of nitric oxide (NO) in the gastric mucosa of AA rats were also increased by the administration of indomethacin. The co-administration of BWs decreased the ulcerogenic response to indomethacin in AA rats. In addition, the administration of BW attenuated the increase in iNOS mRNA expression and NO production in AA rats receiving indomethacin. The oral administration of Mg^<2+> to AA rats had a potent preventive effect on the ulcerogenic response to indomethacin in AA rats, probably due to an inhibition in the rise in iNOS and NO levels in the gastric mucosa.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
-
Nagai Noriaki
School of Pharmacy, Kinki University
-
Ito Yoshimasa
School of Pharmacy, Kinki University
-
HIRANO Kazuyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
-
Ito Yoshimasa
School Of Pharmacy Kinki Univ.
-
Nagai Noriaki
School Of Pharmacy Kinki Univ.
-
Nagai Noriaki
School Of Pharmaceutical Sciences Kindai University
-
USUI Shigeyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
-
FUKUHATA Takashi
School of Pharmaceutical Sciences, Kindai University
-
Ito Yoshimasa
School Of Pharmacy Kindai University:pharmaceutical Research And Technology Institute Kindai Univers
-
Ito Yoshimasa
School Of Pharmaceutical Sciences Kinki University:pharmaceutical Research And Tchnology Institute K
-
Hirano K
Lab. Of Pharmaceutics Gifu Pharmaceutical Univ.
-
Hirano K
Gifu Pharmaceutical University
-
Hirano Kazuyuki
Laboratory Of Pharmaceutics Gifu Pharmaceutical University
-
Shigeyuki Usui
Gifu Pharmaceutical University
-
Usui Shigeyuki
Laboratory Of Pharmaceutics Gifu Pharmaceutical University
-
Ito Yoshimasa
School Of Pharmaceutical Sciences Kinki University
-
Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
-
Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
-
Fukuhata Takashi
School Of Pharmaceutical Sciences Kindai University
-
Nagai Noriaki
School of Pharmaceutical Sciences, Kindai University
-
Nagai Noriaki
School of Pharmaceutical science, Kinki University
-
Ito Yoshimasa
School of Pharmaceutical science, Kinki University
-
Horie Kazutoshi
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
関連論文
- Comparison of Corneal Wound Healing Rates after Instillation of Commercially Available Latanoprost and Travoprost in Rat Debrided Corneal Epithelium
- Enhancing Effects of Sericin on Corneal Wound Healing in Otsuka Long-Evans Tokushima Fatty Rats as a Model of Human Type 2 Diabetes
- Enhancing Effects of Sericin on Corneal Wound Healing in Rat Debrided Corneal Epithelium
- Preparation of Ophthalmic Formulations Containing Cilostazol as an Anti-glaucoma Agent and Improvement in Its Permeability through the Rabbit Cornea
- Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)
- Contribution of Aldehyde Dehydrogenase 3A1 to Disulfiram Penetration through Monolayers Consisting of Cultured Human Corneal Epithelial Cells(Biopharmacy)
- Activation of Caspase-3, Proteolytic Cleavage of DFF and No Oligonucleosomal DNA Fragmentation in Apoptotic Molt-4 Cells
- Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells.
- Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells^1
- Decreased Thymosinβ_4 in Apoptosis Induced by a Variety of Antitumor Drugs.
- Regulation of Glyceraldehyde 3-Phosphate Dehydrogenase Expression by Metformin in HepG2 Cells
- Kinetic Analysis of the Rate of Corneal Wound Healing in Otsuka Long-Evans Tokushima Fatty Rats, a Model of Type 2 Diabetes Mellitus
- Disulfiram Reduces Elevated Blood Glucose Levels in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats, a Model of Type 2 Diabetes
- Aminopeptidase N Regulated by Zinc in Human Prostate Participates in Tumor Cell Invasion.
- Decreases of Metallothionein and Aminopeptidase N in Rental Cancer Tissues.
- Decreases of Metallothionein and Aminopeptidase N in Renal Cancer Tissues
- CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO COMPOUNDS
- Preventive Effect of Co-administration of Water Containing Magnesium Ion on Indomethacin Induced Lesions of Gastric Mucosa in Adjuvant-Induced Arthritis Rat(Biopharmacy)
- Preventive Effect of Water Containing Magnesium Ion on Paw Edema in Adjuvant-Induced Arthritis Rat(Biopharmacy)
- Effect of Magnesium Deficiency on Intracellular ATP Levels in Human Lens Epithelial Cells(Biochemistry)
- Inhibitors of Inducible Nitric Oxide Synthase Prevent Damage to Human Lens Epithelial Cells Induced by Interferon-Gamma and Lipopolysaccharide(Biopharmacy)
- Comparison of the Mechanisms of Cataract Development Involving Differences in Ca^ Regulation in Lenses among Three Hereditary Cataract Model Rats(Biochemistry)
- Effect of Disulfiram Eye Drops on Lipid Peroxide Formation via Excessive Nitric Oxide in Lenses of Hereditary Cataract ICR/f Rats(Biopharmacy)
- Effects of Magnesium Content in the Feed on Cataract Development in Shumiya Cataract Rat
- Delay of Cataract Development in the Shumiya Cataract Rat by the Administration of Drinking Water Containing High Concentration of Magnesium Ion(Biopharmacy)
- Delay in ICR/f Rat Lens Opacification by the Instillation of Eye Drops Containing Disulfiram and Hydroxypropyl-β-cyclodextrin Inclusion Complex(Biopharmacy)
- Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups
- Comparative Study of Superoxide Dismutase in Normal and Hereditary Cataract (UPL) Rats
- Effects of Lipid Composition on the Transcorneal Penetration of Liposomes Containing Disulfiram, a Potential Anti-cataract Agent, in the Rabbit
- Aminoguanidine-Treatment Results in the Inhibition of Lens Opacification and Calpain-Mediated Proteolysis in Shumiya Cataract Rats (SCR)^1
- Involvement of DNase II-Like Acid DNase in the Cataract Formation of the UPL Rat and the Shumiya Cataract Rat(Biochemistry)
- Involvement of Interleukin 18 in Cataract Development in Hereditary Cataract UPL Rats
- Inhibition of Aminopeptidase N (AP-N) and Urokinase-Type Plasminogen Activator (uPA) by Zinc Suppresses the Invasion Activity in Human Urological Cancer Cells.
- Extract from Serenoa repens Suppresses the Invasion Activity of Human Urological Cancer Cells by Inhibiting Urokinase-Type Plasminogen Activator.
- Inhibition of Aminopeptidase N(AP-N)and Urokinase-Type Plasminogen Activator(uPA)by Zinc Suppresses the Invasion Activity in Human Urological Cancer Cells
- Extract from Serenoa repens Suppresses the Invasion Activity of Human Urological Cancer Cells by Inhibiting Urokinase-Type Plasminogen Activator
- Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis.
- Toxic Shock Syndrome and Pharmacokinetics of Vancomycin.
- Pharmacokinetics of Granisetron in Adults and Children with Malignant Diseases
- A Rapid Assay of Granisetron in Biological Fluids from Cancer Patients.
- A Rapid Assay of Granisetron in Biological Fluids from Cancer Patients
- The Effect of Ethanolamine on Acute Carbon Tetrachloride Intoxication
- Buformin Suppresses the Expression of Glyceraldehyde 3-Phosphate Dehydrogenase(Biopharmacy)
- Regulators for Blood Glucose Level Affect Gene Expression of Aquaporin 3(Biopharmacy)
- Identification of Differentially Expressed Genes in Hepatic HepG2 Cells Treated with Acetaminophen Using Suppression Subtractive Hybridization(Biochemistry)
- Sentinel node navigation surgery using endoscopic minilaparotomy technique for patients with prostate cancer
- Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction(Biopharmacy)
- Myristoleic Acid, a Cytotoxic Component in the Extract from Serenoa repens, Induces Apoptosis and Necrosis in Human Prostatic LNCaP Cells.
- Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines.
- Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines
- Determination of Human Alkaline Phosphatase Isozymes by Use of Monoclonal Antibodies and their Clinical Application
- Tomato Paste Fraction Inhibiting the Formation of Advanced Glycation End-products
- Antidiabetic Effect of an Acidic Polysaccharide (TAP) from Tremella aurantia and Its Degradation Product (TAP-H).
- Antidiabetic Effect of an Acidic Polysaccharide(TAP)from Tremella aurantia and Its Degradation Product(TAP-H)
- Structural Features of an Anti-Diabetic Polysaccharide(TAP) from Tremella aurantia.
- Structural Features of an Anti-Diabetic Polysaccharide (TAP) from Tremella aurantia
- Structural Features and Hypoglycemic Activity of a Polysaccharide(CS-F10) from the Cultured Mycelium of Cordyceps sinensis.
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor.
- Growth Suppressing Factor for Endothelial Cells Exhibits Tumor Regressing Activity.
- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells.
- Structural Features and Hypoglycemic Activity of a Polysaccharide (CS-F10) from the Cultured Mycelium of Cordyceps sinensis
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor
- Growth Suppressing Factor for Endothelial Cells Exhibits Tumor Regressing Activity
- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells
- Preparation and Antitumor Activities of β-(1→6)Branced(1→3)-β-D-Glucan Derivatives.
- Polysaccharides in Fungi. XXXV. : Anti Diabetic Activity of an Acidic Polysaccharide from the Fruiting Bodies of Tremella aurantia.
- Preparation and Antitumor Activities of Mitomycin C-(1→6)-Branched (1→3)-β-D-Glucan Conjugate.
- Polysaccharides in Fungi. XXXVIII. Anti-diabetic Activity and Structural Feature of a Galactomannan Elaborated by Pestalotiopsis Species
- Overexpression of Thymosin β4 Increases Pseudopodia Formation in LNCaP Prostate Cancer Cells
- Effect of a Polysaccharide(TAP) from the Fruiting Bodies of Tremella aurantia on Glucose Metabolism in Mouse Liver.
- Effect of a Polysaccharide (TAP) from the Fruiting Bodies of Tremella aurantia on Glucose Metabolism in Mouse Liver
- A highly sensitive assay for ritodrine in human serum by hydrophilic interaction chromatography-tandem mass spectrometry
- Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface.
- Polysaccharides in Fungi. XXXVII. : Immunomodulating Activities of Carboxymethylated Derivatives of Linear (1→3)-α-D-Glucans Extracted from the Fruiting Bodies of Agrocybe cylindracea and Amanita muscaria.
- Polysaccharides in Fungi. XXXVII. Immunomodulating Activities of Carboxymethylated Derivatives of Linear (1→3)-α-D-Glucans Extracted from the Fruiting Bodies of Agrocybe cylindracea and Amanita muscaria
- Polysaccharides in Fungi. XXXIV. : A Polysaccharide from the Fruiting Bodies of Amanita muscaria and the Antitumor Activity of Its Carboxymethylated Product.
- The Distribution of Carboxymethyl Groups in O-(Carboxymthyl)ated (1→3)-β-D-Glucans and (1→3)-α-D-Glucans.
- Correlation between Hyper-Sensitivity to Hydrogen Peroxide and Low Defense against Ca2+ Influx in Cataractogenic Lens of Ihara Cataract Rats
- Polysaccharides in Fungi. XXXVIII. : Anti-diabetic Activity and Structural Feature of a Galactomann Elaborated by Pestalotiopsis Species.
- Polysaccharides in Fungi. XXXIII. : Hypoglycemic Activity of an Acidic Polysaccharide (AC) from Tremella fuciformis.
- The Effect of Carbohydrate Sulfate Salts on the Absorption and Excretion of Paraquat in Rats.
- Detoxification of Paraquat Poisoning : Effects of Aromatic Sulfonates on Paraquat Poisoning in Mice and Active Oxygen System.
- Detoxification of Paraquat Poisoning : Effects of Carbohydrate Sulfate, Alkylsulfate and Alkylsulfonate on Active Oxygen.
- Detoxification of Paraquat Poisoning : Effects of Alkylsulfates and Alkylsulfates and Alkylsulfonates on Paraquat Poisoning in Mice and Rats.
- Effect of 3-Deoxyglucosone on the Activities of Enzymes Responsible for Glucose Metabolism in Mouse Liver.
- EFFECT OF 3-DEOXYGLUCOSONE ON THE ACTIVITIES OF ENZYMES RESPONSIBLE FOR GLUCOSE METABOLISM IN MOUSE LIVER
- Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains.
- Growth Suppressing Activity for Endothelial Cells Induced from Macrophages by Carboxymethylated Curdlan.
- Preparation of Novel(1→3)-β-D-Glucans Having Reducing Glucose Side Chains.
- Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains
- Growth Suppressing Activity for Endothelial Cells Induced from Macrophages by Carboxymethylated Curdlan
- Polysaccharides in Fungi. XXXVI. : Hypoglycemic Activity of a Polysaccharide (CS-F30) from the Cultural Mycelium of Cordyceps seninsis and Its Effect on Glucose Metabolism in Mouse Liver.
- Polysaccharides in Fungi. XXXVI. Hypoglycemic Activity of a Polysaccharide (CS-F30) from the Cultural Mycelium of Cordyceps sinensis and Its Effect on Glucose Metabolism in Mouse Liver
- Polysaccharides in Fungi. XXXII. : Hypoglycemic Activity and Chemical Properties of a Polysaccharide from the Cultural Mycelium of Cordyceps sinensis.
- Polysaccharides in Fungi. XXX. : Antitumor and Immunomodulating Activities of Two Polysaccharides from the Fruiting Bodies of Armillariella tabescens.
- Preparation of Novel (1→3)-β-D-Glucans Having Reducing Glucose Side Chains
- The Recovering Effect of Betaine on Carbon Tetrachloride-Induced Liver Injury
- Preventive Effect of Co-administration of Water Containing Magnesium Ion on Indomethacin Induced Lesions of Gastric Mucosa in Adjuvant-Induced Arthritis Rat
- Co-administration of Water Containing Magnesium Ion Prevents Loxoprofen-Induced Lesions in Gastric Mucosa of Adjuvant-Induced Arthritis Rat
- Therapeutic Effects of Gel Ointments Containing Tranilast Nanoparticles on Paw Edema in Adjuvant-Induced Arthritis Rats