Polysaccharides in Fungi. XXXVIII. Anti-diabetic Activity and Structural Feature of a Galactomannan Elaborated by Pestalotiopsis Species
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概要
- 論文の詳細を見る
A fungus of Pestalotiopsis species produced an extracellular, water-soluble polysaccharide (PS-N). PS-N exhibited significant hypoglycemic activity in streptozotocin-induced diabetic mice following intraperitoneal administration and had an effect on oral glucose tolerance in normal mice following oral administration. PS-N ([α]_D+34.5° in water) was homogeneous on gel chromatography, it is composed of galactose and mannose in a molar ratio of 1 : 9,and its molecular weight was estimated by gel chromatography to be about 24000. Its structure was investigated by a combination of chemical and spectroscopic methods. The results indicated that PS-N, a highly branched galactomannan, is composed of β-(1→3)-linked D-galactofuranosyl and non-reducing terminal β-D-galactofuranosyl residues, in addition to α-D-mannopyranosyl residues of a yeast mannan type.
- 1997-02-15
著者
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Ishiguro Yukio
Research Institute Kagome Co. Ltd.
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MORI Hironobu
Research Institute, Kagome Co., Ltd.,
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USUI Shigeyuki
Gifu Pharmaceutical University
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UKAI Shigeo
Gifu Pharmaceutical University
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Sakamoto Hideki
Research Institute, Kagome Co., Ltd.
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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Kiho T
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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ISHIGURO Yukio
Kagome Co., Ltd.
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Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
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Kiho T
Gifu Pharmaceutical Univ. Gifu Jpn
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SAKUSHIMA Miho
Gifu Pharmaceutical University
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Mori Hironobu
Research Institute Kagome Co. Ltd.
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ITAHASHI Sadahito
Gifu Pharmaceutical University
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MATSUNAGA Toshiyuki
Gifu Pharmaceutical University
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Ishiguro Yukio
Kagome Co. Ltd.
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Sakamoto Hideki
Research Institute Kagome Co.
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