EFFECTIVENESS OF DEXTRAN SULFATE ON ACUTE TOXICITY OF PARAQUAT IN MICE AND RATS
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概要
- 論文の詳細を見る
The alleviation of acute toxicity of paraquat dichloride (PQ) by sodium dextran sulfate (DS), which is clinically used for antihyperlipemia was studied in mice and rats. When mice were orally given DS (2000 mg/kg) or sodium polystylene sulfonate (SPS), (2000 mg/kg) within 1 h (0,10,20,30,60 min) after PQ ingestion (200 mg/kg), the effectiveness of DS in alleviating PQ toxicity was greater than that of SPS. In rats treated with DS (2000 mg/kg) or SPS (2000 mg/kg), within 4 h (0,2,4 h) after PQ administration (200 mg/kg), the effectiveness of DS was less than that of SPS. However, the effectiveness of DS in the alleviation of toxicity was similar to that of SPS, when given to mice and rats (2000 mg/kg) within a short time after PQ ingestion (200 mg/kg). These results suggested that DS might serve as an antidote for acute toxicity of PQ.
- 公益社団法人日本薬学会の論文
著者
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UKAI Shigeo
Gifu Pharmaceutical University
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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TSUCHIYA Teruo
Gifu Prefectural Hospital
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NAGAI Katsuyuki
Gifu Prefectural Hospital
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NOCHIDA YOSHIO
Gifu Pharmaceutical University
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