Isolation of Plasma Cholesterol-Lowering Components from Ningyotake (Polyporus confluens) Mushroom.
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to isolate component(s) which contributes to the hypocholesterolemic action of Ningyotake (Polyporus confluens) mushroom. The mushroom powder was extracted with 80% ethanol, and the extract and residue were fractionated into five fractions according to the solubility to solvents. When each fraction was added to a diet containing 1 % cholesterol and 0.25% sodium cholate and fed to rats, the plasma cholesterol level was significantly decreased only by ethyl acetate-soluble fraction. Therefore, ethyl acetate-soluble fraction was further fractionated by silica gel column chromatography. Two major compounds, which comprised 45.0% and 28.5% of the ethyl acetate-soluble fraction, were obtained in a pure form by the chromatog-raphy, and the compounds were identified as grifolin (2-trans, trans-farnesyl-5-methylresorcinol) and neogrifolin (4-trans, trans-farnesyl-5-methylresorcinol), respectively. The addition of grifolin and neogrifolin to the high cholesterol diet was found to lower plama cholesterol level significantly.
- 財団法人 学会誌刊行センターの論文
著者
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SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Ishiguro Yukio
Research Institute Kagome Co. Ltd.
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Yoshida Satoshi
Research Centre For Radiation Protection National Institute Of Radiological Sciences
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Saeki Shigeru
Department Of Anesthesiology Nihon University School Of Medicine
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Kawagishi Hirokazu
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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Sakamoto Hideki
Research Institute Kagome Co.
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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SUGIYAMA Kimio
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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YOSHIDA Satoshi
Research Institute, Kagome Co., Ltd.
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KAWAGISHI Hirokazu
Department of Agricultural Chemistry, Faculty of Agriculture
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TANAKA Akio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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