1-Methylmalate from Camu-Camu (Myrciaria dubia) Suppressed D-Galactosamine-Induced Liver Injury in Rats
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the protective effects of fruit juices against D-galactosamine (GalN)-induced liver injury, lyophilized fruit juices (total 12 kinds) were fed to rats for 7 d, and then we evoked liver injury by injecting GalN. The juice of camu-camu (Myrciaria dubia) significantly suppressed GalN-induced liver injury when the magnitude of liver injury was assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, although some other juices (acerola, dragon fruit, shekwasha, and star fruit) also tended to have suppressive effects. An active compound was isolated from camu-camu juice by solvent fractionation and silica gel column chromatography. The structure was determined to be 1-methylmalate. On the other hand, malate, 1,4-dimethylmalate, citrate, and tartrate had no significant effect on GalN-induced liver injury. It is suggested that 1-methylmalate might be a rather specific compound among organic acids and their derivatives in fruit juices in suppressing GalN-induced liver injury.
著者
-
KAWAGUCHI Takumi
Department of Digestive Disease Information & Research
-
Akachi Toshiyuki
The United Graduate School Of Agricultural Science Gifu University
-
SHIINA Yasuyuki
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
-
KAWAGISHI Hirokazu
Graduate School of Science and Technology, Shizuoka University
-
MORITA Tatsuya
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
-
SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
-
Kawaguchi Takumi
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
-
Shiina Yasuyuki
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
関連論文
- Hepatoprotective Effects of Flavonoids from Shekwasha (Citrus depressa) against D-Galactosamine-Induced Liver Injury in Rats
- 1-Methylmalate from Camu-Camu (Myrciaria dubia) Suppressed D-Galactosamine-Induced Liver Injury in Rats
- Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis
- The Hypocholesterolemic Action of Lentinus edodes Is Evoked through Alteration of Phospholipid Composition of Liver Microsomes in Rats
- Glycosidic Flavonoids as Rat-Liver Injury Preventing Compounds from Green Tea
- Suppression of D-Galactosamine-Induced Rat Liver Injury by Glycosidic Flavonoids-Rich Fraction from Green Tea
- Suppression of Methionine-Induced Hyperhomocysteinemia by Glycine and Serine in Rats
- Effects of Dietary Eritadenine on the Liver Microsomal Δ6-Desaturase Activity and Its mRNA in Rats(Food & Nutrition Science)
- Eritadenine-induced Alterations of Plasma Lipoprotein Lipid Concentrations and Phosphatidylcholine Molecular Species Profile in Rats Fed Cholesterol-free and Cholesterol-enriched Diets(Food & Nutrition Science)
- Increased Response of Liver Microsomal Δ6-Desaturase Activity to Dietary Methionine in Rats(Food & Nutrition Science)
- Differential Effects of Dietary Casein and Soybean Protein Isolate on Lipopolysaccharide-induced Hepatitis in D-Galactosamine-sensitized Rats(Food & Nutrition Science)
- Effects of Lentinus edodes on Fatty Acid and Molecular Species Profiles of Phosphatidylcholine in Rats Fed Different Levels of Corn Oil(Food & Nutrition Sience)
- Effects of Dietary Eritadenine on Δ6-Desaturase Activity and Fatty Acid Profiles of Several Lipids in Rats Fed Different Fats(Food & Nutrition Science)
- Unusual amino acid derivatives from the mushroom Pleurocybella porrigens
- Production of a Positron Microprobe Using a Transmission Remoderator
- Short-chain inulin-like fructans reduce endotoxin and bacterial translocations and attenuate development of TNBS-induced colitis in rats.
- Hepatic Cystathionine β-Synthase Activity Does Not Increase in Response to Methionine Supplementation in Rats Fed a Low Casein Diet : Association with Plasma Homocysteine Concentrations
- High Casein Diet Decreases Plasma Homocysteine Concentration in Rats
- Hypohomocysteinemic Effect of Cysteine Is Associated with Increased Plasma Cysteine Concentration in Rats Fed Diets Low in Protein and Methionine Levels
- Choline Deprivation Induces Hyperhomocysteinemia in Rats Fed Low Methionine Diets
- High-Casein Diet Suppresses Guanidinoacetic Acid-Induced Hyperhomocysteinemia and Potentiates the Hypohomocysteinemic Effect of Serine in Rats
- Long-term ingestion of insoluble dietary fiber increases luminal mucin content, but has no effect on nutrient absorption in rats
- Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats
- Dietary Indigestible Components Exert Different Regional Effects on Luminal Mucin Secretion through Their Bulk-Forming Property and Fermentability
- Dietary Resistant Starch Alters the Characteristics of Colonic Mucosa and Exerts a Protective Effect on Trinitrobenzene Sulfonic Acid-induced Colitis in Rats
- Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats
- Suppression of Methionine-Induced Hyperhomocysteinemia by Dietary Eritadenine in Rats
- Osteoclast-Forming Suppressive Compounds from Makomotake, Zizania latifolia Infected with Ustilago esculenta
- Suppressive Effect of Coffee on Lipopolysaccharide-induced Hepatitis in D-Galactosamine-sensitized Rats(Food & Nutrition Science)
- Suppressive Effect of Caffeine on Hepatitis and Apoptosis Induced by Tumor Necrosis Factor-α, but Not by the Anti-Fas Antibody, in Mice
- Suppression of Lipopolysaccharide-induced Liver Injury by Various Types of Tea and Coffee in D-Galactosamine-sensitized Rats
- Green Tea Suppresses D-Galactosamine-Induced Liver Injury in Rats
- Purification of β-Glucan Synthase II from Suspension-cultured Rice Cells
- Characterization and Solubilization of β-Glucan Synthases from Cultured Rice Cells
- Endoplasmic Reticulum (ER) Stress-Suppressive Compounds from Scrap Cultivation Beds of the Mushroom Hericium erinaceum
- Syntheses of Naturally Occurring Terphenyls and Related Compounds
- Effect of dietary soybean protein level on the plasma homocysteine concentration in rats
- Cysteine Supplementation Decreases Plasma Homocysteine Concentration in Rats Fed on a Low-Casein Diet in Rats
- Increased Plasma Homocysteine Concentration in Rats from a Low Casein Diet
- Estimation of Luminal Mucin Content in Rats by Measurement of O-Linked Oligosaccharide Chains and Direct ELISA
- Partial Replacement of Waxy Cornstarch by Recrystallized Amylose Retards the Development of Insulin Resistance in Rats
- Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-cholesterol Diet
- Increasing Muscle Strength and Mass of Thigh in Elderly People with the Hybrid-Training Method of Electrical Stimulation and Volitional Contraction
- Suppression of D-Galactosamine-induced Liver Injury by Mushrooms in Rats
- Facile and Large-Scale Synthesis of L-Theanine
- Effect of Cholesterol-loading on Plasma and Tissue Taurine Levels in Rats
- Comparison between the Plasma Cholesterol-elevating Effects of Caffeine and Methionine in Rats on a High Cholesterol Diet(Food & Nutrition)
- Effects of Excess D- and L-Methionine Diets on Growth and Hepatic Enzyme Activities in Rats(Food & Nutrition)
- Correlation of the Plasma Cholesterol-lowering Effect of Dietary Glycine with the Alteration of Hepatic Phospholipid Composition in Rats
- Differential Effects of Dietary Choline and Methionine on Plasma Lipid Levels in Rats Fed on a High Cholesterol Diet(Food & Nutrition)
- Long-Term Ingestion of Insoluble Dietary Fiber Increases Luminal Mucin Content, but Has No Effect on Nutrient Absorption in Rats
- Estimation of Luminal Mucin Content in Rats by Measurement of O-Linked Oligosaccharide Chains and Direct ELISA
- 1-Methylmalate from Camu-Camu (Myrciaria dubia) Suppressed D-Galactosamine-Induced Liver Injury in Rats
- High-Casein Diet Suppresses Guanidinoacetic Acid-Induced Hyperhomocysteinemia and Potentiates the Hypohomocysteinemic Effect of Serine in Rats
- Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats
- Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats
- Effect of dietary soybean protein level on the plasma homocysteine concentration in rats
- Cysteine Supplementation Decreases Plasma Homocysteine Concentration in Rats Fed on a Low-Casein Diet in Rats
- Purification, Characterization, and cDNA Cloning of a Lectin from the Mushroom Pleurocybella porrigens
- Endoplasmic Reticulum (ER) Stress-Suppressive Compounds from Scrap Cultivation Beds of the Mushroom Hericium erinaceum
- Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD : a pilot study
- Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta
- Methionine and Serine Synergistically Suppress Hyperhomocysteinemia Induced by Choline Deficiency, but Not by Guanidinoacetic Acid, in Rats Fed a Low Casein Diet
- Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats
- Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
- Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
- Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
- Isolation of Bioactive Steroids from the Stropharia rugosoannulata Mushroom and Absolute Configuration of Strophasterol B
- Appearance-specific Satiety Increases Appetite and Quality of Life in Patients with Metastatic Liver Tumor: A Case Report
- Isolation of Plasma Cholesterol-Lowering Components from Ningyotake (Polyporus confluens) Mushroom.
- Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia : a randomized, open-label, phase II study
- Data mining reveals complex interactions of risk factors and clinical feature profiling associated with the staging of non-hepatitis B virus/non-hepatitis C virus-related hepatocellular carcinoma
- Development of intrahepatic cholangiocarcinoma after a 14-year follow-up of a patient with primary sclerosing cholangitis and ulcerative colitis
- Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis : A preliminary, prospective, open-label study
- noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels