Increased Response of Liver Microsomal Δ6-Desaturase Activity to Dietary Methionine in Rats(Food & Nutrition Science)
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概要
- 論文の詳細を見る
The effects of dietary casein level (5-40%) on the liver microsomal phospholipid profile, Δ6-desaturase activity and related variables were investigated in rats to examine whether the dietary protein level affected the Δ6-desaturase activity through an alteration of the liver microsomal phospholipid profile. The effects of supplementing a 10% casein diet with certain amino acids were also investigated. The concentration of hepatic Sadenosylmethionine (SAM), the ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) and the Δ6-desaturase activity in liver microsomes, and the ratio of arachidonate to linoleate of microsomal PC increased with increasing dietary casein level. There were significant correlations between the dietary methionine content and hepatic SAM concentration, hepatic SAM concentration and microsomal PE concentration, and microsomal PE concentration and Δ6-desaturase activity. Supplementation of the 10% casein diet with methionine significantly increased the hepatic SAM concentration, PC/PE ratio, Δ6-desaturase activity, and arachidonate/linoleate ratio, whereas cystine supplementation had no or little effect on these variables. These increases induced by methionine were significantly suppressed by additional glycine. The results obtained here, together with those in our previous report, suggest that quantity and type of dietary protein might affect the Δ6-desaturase activity through an alteration of the liver microsomal profile of phospholipids, especially PE, and that the alteration of phospholipid profile might be mediated by a hepatic SAM concentration that reflects the dietary methionine level.
- 社団法人日本農芸化学会の論文
- 2003-04-23
著者
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MORITA Tatsuya
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Sugiyama Kimio
静岡大学 農 応用生物化学科
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Sugiyama Kimio
静岡大学 農学部応用生物化学
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Morita Tatsuya
静岡大学 農学部応用生物化学
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Morita Tatsuya
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Morita Tatsuya
Dep. Of Applied Biological Chemistry Fac. Of Agriculture Shizuoka Univ.
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SHIMADA Yasuhiko
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Shimada Yukihisa
Tsukuba Research Laboratories Kyowa Hakko Co. Ltd.:(present Address)plant Functions Laboratory The I
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杉山 公男
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama K
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
岐阜大学 連合農学研究科
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Morita T
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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杉山 公男
静岡大学 農学部応用生物化学科
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Shimada Yasuhiko
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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SUGIYAMA Kimio
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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