Isomer-Specific Anti-Obese and Hypolipidemic Properties of Conjugated Linoleic Acid in Obese OLETF Rats
スポンサーリンク
概要
- 論文の詳細を見る
Conjugated linoleic acid (CLA), a mixture of positional and geometric isomers of linoleic acid, has attracted considerable attention because of its potentially beneficial biologic effects both in vitro and in vivo. Our results clearly show the specific action of the 10trans,12cis-CLA isomer against hyperlipidemia and obesity in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. After 2 weeks of feeding with 10t,12c-CLA, but not 9cis,11trans-CLA, abdominal adipose tissue weight and serum and hepatic lipid levels in OLETF rats were lower than those in linoleic acid-fed rats. These effects were attributable to suppressed fatty acid synthesis and enhanced fatty acid beta oxidation in the liver on a 10t,12c-CLA diet. Additionally, we showed that mRNA expression of fatty acid synthase, carnitine palmitoyltransferase, leptin, and sterol regulatory element binding protein-1 was also regulated by 10t,12c-CLA. We suppose that 10t,12c-CLA reveals hypolipidemic and anti-obese activity through the alteration of mRNA expressions in the liver and white adipose tissue.
- 社団法人 日本農芸化学会の論文
- 2006-02-23
著者
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Tominaga Y
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
佐賀大学 食糧科学
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Yanagita Teruyoshi
Lab. Of Nutrition Biochemistry Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
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Nagao K
School Of Medicine And Center For Aids Research Kumamoto University
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岩田 敏夫
リノール油脂
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Inoue Nao
Department of Cardiology, Juntendo University School of Medicine
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YANAGITA Teruyoshi
Department of Applied Biological Sciences, Saga University
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Kai Takanori
Res. Inst. Unkai Shuzo Co. Ltd.
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NAGAO Toshihiro
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medic
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Nagao Koji
Department of Applied Biochemistry and Food Science, Saga University
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Wang Yu-ming
Department Of Applied Biological Sciences Saga University
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Inoue Nao
佐賀大学 食糧科学
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Shimada Y
Department Of Biochemistry Osaka Municipal Technical Research Institute
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Shimada Y
Department Of Physics Chuo University:tecmo
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Nagao Koji
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
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Nagao Koji
Department Of Applied Biochemistry And Food Science Saga University
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Nagao Koji
Department Of Applied Biological Sciences Saga University
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Nagao Koji
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
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UJINO Yoko
Department of Applied Biological Sciences, Saga University
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SHIMADA Yuji
Department of Biochemistry, Osaka Municipal Technical Research Institute
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IWATA Toshio
Research Laboratory, The Nisshin OilliO Group, Ltd.
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KAMEGAI Takeshi
Research Laboratory, The Nisshin OilliO Group, Ltd.
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YAMAUCHI SATO
Research Laboratory, The Nisshin OilliO Group, Ltd.
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Nagao Kazuhiko
Faculty Of Pharmaceutical Sciences Kumamoto University
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Shimada Yukihisa
Tsukuba Research Laboratories Kyowa Hakko Co. Ltd.:(present Address)plant Functions Laboratory The I
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Yanagita Teruyoshi
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Saga University
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Ujino Yoko
Department Of Applied Biological Sciences Saga University
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Iwata Toshio
Research Laboratory The Nisshin Oillio Group Ltd.
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Iwata Toshio
Division Of Research And Development Rinoru Oil Mills Co. Ltd.
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Iwata Toshio
Rinoru Oil Mills
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Yamauchi Sato
Research Laboratory The Nisshin Oillio Group Ltd.
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Nagao Toshihiro
Biomaterials And Commodity Chemicals Res. Div. Osaka Municipal Technical Res. Inst.
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Nagao Toshihiro
Department Of Agricultural Chemistry School Of Agriculture Nagoya University
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Nagao Toshihiro
Department Of Biochemistry Osaka Municipal Technical Research Institute
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Kai Takanori
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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Inoue Nao
Department Of Applied Biochemistry And Food Science Saga University
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Inoue Nao
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku University
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