Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats
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概要
- 論文の詳細を見る
Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion.
- 日本油化学会の論文
- 2003-03-01
著者
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NAGAO Koji
Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
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YANAGITA Teruyoshi
Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
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Tominaga Y
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
佐賀大学 食糧科学
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Yanagita Teruyoshi
Lab. Of Nutrition Biochemistry Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
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Nagao K
School Of Medicine And Center For Aids Research Kumamoto University
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Wang Yu-ming
Department Of Applied Biological Sciences Saga University
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Rahman Shaikh
Department Of Biochemistry University Of Wisconsin-madison
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Rahman Shaikh
Department Of Applied Biological Sciences Faculty Of Agriculture Saga University
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Cha Jae-young
Biohub Co. Ltd.
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Cha J‐y
Department Of Applied Biological Sciences Saga University
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Nagao Koji
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
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Nagao Koji
Department Of Applied Biological Sciences Saga University
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Nagao Koji
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
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HAN Seo-young
Department of Applied Biological Sciences, Saga University
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Han Seo-young
Department Of Applied Biological Sciences Saga University
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BUANG Yohanes
Department of Applied Biological Sciences, Saga University
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WANG Yu-Ming
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
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HAN Seo-Young
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
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BUANG Yohanes
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
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CHA Jae-Young
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
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Nagao Kazuhiko
Faculty Of Pharmaceutical Sciences Kumamoto University
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Yanagita Teruyoshi
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
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Yanagita Teruyoshi
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
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Buang Yohanes
Department Of Applied Biological Sciences Saga University
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Yanagita Teruyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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