Physiological Functions of iso-type Short-Chain Fatty Acid and Omega 3 Polyunsaturated Fatty Acids Containing Oil in Obese OLETF Rats
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概要
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It has been known that tissues of porpoise contain unique structured-lipids as combination of iso-valeric acid (iso-C5:0) and omega 3 polyunsaturated fatty acids (ω3 PUFAs). It is well known that ω3 PUFAs have lipid-lowering effects in animal and human studies. Although branched chain fatty acids have been interested in their unique functions, there is no data concerning the effect of iso-C5:0 on lipid metabolism. In this study we investigated the effect of structured-lipids from porpoise adipose tissue (porpoise oil) on lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. For 4 weeks, rats were fed semisynthetic diets containing either 10% corn oil or 5% corn oil plus 5% porpoise oil. After feeding period, the porpoise oil diet significantly alleviated hepatic triglyceride accumulation compared with the control diet in OLETF rats. Although serum triglyceride level increased, serum level of adiponectin that can protect liver function and alleviate abnormalities of lipid and glucose metabolism increased in rats fed porpoise oil diet. In conclusion, results from the present study suggest that porpoise oil feeding prevents the development of fatty liver disease through the enhancement of lipoprotein secretion and increase of adiponectin production in obese rats.
著者
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NAGAO Koji
Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
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YANAGITA Teruyoshi
Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
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Shirouchi Bungo
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga Univ
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Furuya Kenta
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga Univ
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Nagai Toshiharu
Tsukishima Foods Industry Co., Ltd.
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Ichioka Kenji
Tsukishima Foods Industry Co., Ltd.
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Tokairin Shigeru
Tsukishima Foods Industry Co., Ltd.
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Iida Yasuhiro
Japan Institute for Oils & Fats & Foods Inspection
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Nagao Koji
Department Of Applied Biological Sciences Saga University
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Nagao Koji
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
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Yanagita Teruyoshi
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
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Furuya Kenta
Department Of Applied Biochemistry And Food Science Saga University
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Yanagita Teruyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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Ichioka Kenji
Tsukishima Foods Industry Co. Ltd.
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Iida Yasuhiro
Japan Institute for Oils & Fats & Foods Inspection
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Tokairin Shigeru
Tsukishima Foods Industry Co. Ltd.
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Furuya Kenta
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University
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Nagao Koji
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University
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Nagai Toshiharu
Tsukishima Foods Industry Co. Ltd.
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