Alleviation of Fatty Liver by α-Linolenic Acid
スポンサーリンク
概要
- 論文の詳細を見る
We compared the efficacy of alpha-linolenic acid (α-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats. Rats were fed semi-synthetic diets containing either LA or α-LNA with or without 1% OA for 2 wk. OA supplementation lowered serum lipids in LA+OA groups. In addition to the decline of serum lipids in α-LNA groups compared to LA groups, a further decrease was found in α-LNA+OA groups compared to LA+OA groups. OA-containing diets significantly increased the liver weights and triacylglycerol (TG) accumulations compared with the OA-free diets. These results were attributed to the significant increases in the activities of phosphatidate phosphohydrolase (PAP), a rate-limiting enzyme of TG synthesis, and glucose-6-phosphate dehydrogenase, a fatty acid synthesis-related enzyme. However, the increase of PAP activity was significantly less in the α-LNA+OA group as compared with the LA+OA group. These results suggest that dietary α-LNA alleviates OA-induced hepatic TG accumulation through the attenuation of hepatic TG synthesis in rats.
- 日本ビタミン学会の論文
著者
-
Tominaga Y
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
-
Yanagita Teruyoshi
佐賀大学 食糧科学
-
Yanagita Teruyoshi
Lab. Of Nutrition Biochemistry Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
-
Yanagita Teruyoshi
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
-
Nagao K
School Of Medicine And Center For Aids Research Kumamoto University
-
Inoue Nao
Department of Cardiology, Juntendo University School of Medicine
-
YANAGITA Teruyoshi
Department of Applied Biological Sciences, Saga University
-
Nagao Koji
Department of Applied Biochemistry and Food Science, Saga University
-
Wang Yu-ming
Department Of Applied Biological Sciences Saga University
-
Inoue Nao
佐賀大学 食糧科学
-
Cha Jae-young
Biohub Co. Ltd.
-
Cha J‐y
Department Of Applied Biological Sciences Saga University
-
Nagao Koji
Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University
-
Nagao Koji
Department Of Applied Biochemistry And Food Science Saga University
-
Nagao Koji
Department Of Applied Biological Sciences Saga University
-
Nagao Koji
Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University
-
BUANG Yohanes
Department of Applied Biological Sciences, Saga University
-
Nagao Kazuhiko
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Yanagita Teruyoshi
Dep. Of Applied Biochemistry And Food Sci. Saga Univ.
-
Yanagita Teruyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Saga University
-
Buang Yohanes
Department Of Applied Biological Sciences Saga University
-
Inoue Nao
Department Of Applied Biochemistry And Food Science Saga University
-
Inoue Nao
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku University
-
Cha Hae-Yong
Biohub Co., Ltd.
関連論文
- Physiological Functions of iso-type Short-Chain Fatty Acid and Omega 3 Polyunsaturated Fatty Acids Containing Oil in Obese OLETF Rats
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- DPE-063 Prognostic Value of Urinary Liver-type Fatty Acid-Binding Protein (L-FABP) in Patients with Acute Coronary Syndrome(DPE11,Kidney/Renal Circulation/CKD (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
- Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
- Imaging of aortico-left ventricular tunnel by three-dimensional echocardiography
- Effect of Vaccinium ashei reade Leaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats
- Purification and Characterization of a Novel Cholesterol Esterase from Pseudomonas aeruginosa, with Its Application to Cleaning Lipid-stained Contact Lenses(Biochemistry & Molecular Biology)
- Involvement of Vascular Angiotensin II-Forming Enzymes in the Progression of Aortic Abdominal Aneurysms in Angiotensin II-Infused ApoE-Deficient Mice
- Folimycin (concanamycin A) and Bafilomycin A_1, Inhibitors Specific for V-ATPase,Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins
- Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intra-cellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus
- Fattiviracin A1, a Novel Antiviral Agent Produced by Streptomyces microflavus Strain No. 2445 II. Biological Properties
- PJ-772 Higher Morbidity of Perioperative Intracranial Complications of Open Heart Surgery in Neonates and Infants without Any Neurological Symptoms(PJ130,Congenital Heart Disease/Kawasaki's Disease (M),Poster Session (Japanese),The 73rd Annual Scientific
- Linoleic Acid-Menthyl Ester Reduces the Secretion of Apolipoprotein B100 in HepG2 Cells
- The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells
- The 9cis, 11trans, 13cis Isomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells
- S-Propyl-Cysteine Sulfoxide and DL-Methionine Sulfoxide Inhibit the Secretion of Apolipoprotein B100 and Lipids in HepG2 Cells
- Effect of long-term incubation of eicosapentaenoic acid and docosahexaenoic acid on triacylglycerol metabolism in HepG2 cells
- OJ-199 Role of Chymase and MMPs in Angiotensin II-induced Abdominal Aortic Aneurysms(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D
- Hypertriglyceridemia in Rats Induced by Consumption of a Food-derived Carcinogen, 2-Amino-1-methyl-phenylimidazo [4,5b] pyridine (PhIP)
- PJ-390 Clinical Evidence of Activation of Monocyte-derived Dendritic Cells in Patients with Acute Coronary Syndrome(PJ066,ACS/AMI (Basic) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
- Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 II. Physico-chemical Properties and Structure Elucidation
- Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 I. Taxonomy, Fermentation, Isolation and Biological Activities
- Conjugated Fatty Acids in Food and Their Health Benefits
- Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis
- Combined Effects of Pravastatin and Probucol on High-Density Lipoprotein Apolipoprotein A-I Kinetics in Cholesterol-fed Rabbits
- Serum levels of remnant lipoprotein cholesterol and oxidized low-density lipoprotein in patients with coronary artery disease
- Feeding Unsaponifiable Compounds from Rice Bran Oil Does Not Alter Hepatic mRNA Abundance for Cholesterol Metabolism-related Proteins in Hypercholesterolemic Rats
- Superiority of Dietary Safflower Oil over Olive Oil in Lowering Serum Cholesterol and Increasing Hepatic mRNAs for the LDL Receptor and Cholesterol 7α-Hydroxylase in Exogenously Hypercholesterolemic (ExHC) Rats
- Isomer-Specific Anti-Obese and Hypolipidemic Properties of Conjugated Linoleic Acid in Obese OLETF Rats
- Short-Term Feeding of Conjugated Linoleic Acid Does Not Induce Hepatic Steatosis in C57BL/6J Mice
- Alleviation of Fatty Liver by α-Linolenic Acid
- Purification of Conjugated Linoleic Acid Isomers through a Process Including Lipase-catalyzed Selective Esterification(Biochemistry & Molecular Biology)
- Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats
- Comparison of the Effects of Triacylglycerol-CLA and Free Fatty Acid-CLA on Hepatic Lipid Metabolism in OLETF Obese Rats
- Methyl Esterification of Waste Fatty Acids with Immobilized Candida antarctica Lipase
- A New Type of Aminoacyltransferase from Saccharothrix sp. AS-2 Favorable for the Synthesis of D-Amino Acid-Containing Peptides
- Ethyl Esterification of Docosahexaenoic Acid in an Organic Solvent-Free System with Immobilized Candida antarctica Lipase
- A Novel α-Amino-Acid Esterase from Bacillus mycoides Capable of Forming Peptides of DD- and DL-Configurations
- Enzymatic Purification of Polyunsaturated Fatty Acids
- 固定化Rhizomucor mieheiリパーゼによる選択的アルコリシス反応を利用したドコサヘキサエン酸エチルの精製
- Amino Acid Residues Contributing to Stabilization of Fusarium heterosporum Lipase
- Stepwise Ethanolysis of Tuna Oil Using Immobilized Candida antarctica Lipase
- C-Terminal Peptide of Fusarium heterosporum Lipase Is Neccessary for Its Incrrreasing Thermostability
- Enrichment of Ethyl Docosahexaenoate by Selective Alcoholysis with Immobilized Rhizopus delemar Lipase
- Fatty Acid Specificity of Rhizopus delemar Lipase in Acidolysis
- Penicillium abeanum Lipase : Purification, Characterization, and Its Use for Docosahexaenoic Acid Enrichment of Tuna Oil
- Expression of Lipase cDNA from Fusarium heterosporum by Saccharomyces cerevisiae : High-Level Production and Purification
- Antiviral Activity of Fattiviracin FV-8 against Human Immunodeficiency Virus Type 1 (HIV-1)
- OJ-071 Digital Vascular Function, Cardiovascular Risk Factors, and Circulating Endothelial Progenitor Cells in Patients with Coronary Artery Disease(OJ12,Smoking/Alcohol/Life Style (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The
- DPJ-051 Voluntary Exercise Ameliorates Progression of Atherosclerotic Lesions in Apolipoprotein E-Knockout Mice(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
- Cholesterol Lowering Effect of Sulfur-Containing Amino Acids Added to a Soybean Protein Diet in Rats
- Esterification of Glycosides by a Mono- and Diacylglycerol Lipase from Penicillium camembertii and Comparison of the Products with Candida cylindracea Lipase
- Inhibition of Matrix Metalloproteinase-9 Activity by Trandolapril after Middle Cerebral Artery Occlusion in Rats
- Vibration Exposure and Symptoms in Postal Carriers Using Motorbikes
- Effect of Vaccinium ashei reade Leaves on Angiotensin Converting Enzyme Activity in Vitro and on Systolic Blood Pressure of Spontaneously Hypertensive Rats in Vivo
- Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow
- Production of Structured Lipid Containing Docosahexaenoic and Caprylic Acids Using Immobilized Rhizopus delemar Lipase
- Trans Fatty Acids in Margarines Marketed in Eleven Countries
- Study of trans Fatty Acid Content in Commercial Foods in Japan: 4.Chocolate and Chocolate Confectioery 〔和文〕
- Isolation, Characterization and Identification of Polyhydroxyalkanoate-Accumulating Bacteria from Activated Sludge
- Role of Glycogen in Acetate Uptake and Polyhydroxyalkanoate Synthesis in Anaerobic-Aerobic Activated Sludge with a Minimized Polyphosphate Content
- 277 Polyhydroxyalkanoates Synthesis from Acetate in Anaerobic-Aerobic Activated Sludge with a Minimized Polyphosphate Content
- Propionate Formation from Alcohols or Aldehydes by Desulfobulbus propionicus in the Absence of Sulfate
- Degradation of Benzoate by an Anaerobic Consortium and Some Properties of a Hydrogenotrophic Methanogen and Sulfate-Reducing Bacterium in the Consortium
- Vitamin B_ Production by Acetobacterium sp. and Its Tetrachloromethane-Resistant Mutants
- Growth Characteristics of Batch-Cultured Activated Sludge and Its Phosphate Elimination Capacity : Growth Characteristics of Batch-Cultured Activated Sludge (1)
- Association between Hepatic Triacylglycerol Accumulation Induced by Administering Orotic Acid and Enhanced Phosphatidate Phosphohydrolase Activity in Rats
- Effect of Vaccinium ashei reade Leaves on Angiotensin Converting Enzyme Activity in Vitro and on Systolic Blood Pressure of Spontaneously Hypertensive Rats in Vivo
- Purification and Some Properties of a Protease from Streptomyces limosus
- Purification and Characterization of a Carboxylesterase from Pseudomonas sp. KWI-56
- Purification and Characterization of a Novel Solvent-Tolerant Lipase from Fusarium heterosporum
- Linolenic Acid Content in Soybean Improved by X-Ray Irradiation(Food & Nutrition)
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Lipase-Catalyzed Esterification of Mono- and Oligoglycosides with Various Fatty Acids
- Cloning, Nucleotide Sequencing, and Expression in Escherichia coli of a Lipase and Its Activator Genes from Pseudomonas sp. KWI-56(Biological Chemistry)
- Purification and Characterization of a Thermostable Lipase from Newly Isolated Pseudomonas sp. KWI-56(Microbiology & Fermentation Industry)
- Physiological Effects of Dietary PIPS Soybean-Derived Phospholipid in Obese Zucker (fa-fa) Rats
- The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells
- Effect of Vaccinium ashei reade Leaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats
- Syntheses of Glucosides with Trimethylolpropane and Two Related Polyol Moieties by Cyclodextrin Glucanotransferase and Their Esterification by Lipase
- Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats
- Induction of Geotrichum candidum Lipase by Long-Chain Fatty Acids
- Purification and Properties of Carboxylesterase from Ochrobactrum anthropi(Biological Chemistry)
- Esterification of Glycosides with Glycerol ant Trimethylolpropane Moieties by Candida cylidracea Lipase(Biological Chemistry)
- Enhanced Stability of a Microbial Lipase Immobilized to a Novel Synthetic Amine Polymer(Biological Chemistry)
- Effects of Phthalate Esters on Liver Lysosomal Acid Lipase and Acid Esterase in Vitro
- Behavior of N-Methylcarbamate Pesticides during Refinement Processing of Edible Oils
- Behavior of 11 Organonitrogen Pesticides during the Refinement of Edible Oils
- Determination of Trace Protein in Oils and Fats by Fluorescence Spectrophotometer
- New phenolic compounds from Camellia sinensis L. leaves fermented with Aspergillus sp.
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
- Effect of Vaccinium ashei reade Leaf Extracts on Lipid Metabolism in Obese OLETF Rats
- Effects of Lotus Root (the Edible Rhizome of Nelumbo nucifera) on the Deveolopment of Non-Alcoholic Fatty Liver Disease in Obese Diabetic db/db Mice
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption-Comparison with Jcl : Wistar and WKY/Izm Rats
- Effects of Lotus Root (the Edible Rhizome of Nelumbo nucifera) on the Deveolopment of Non-Alcoholic Fatty Liver Disease in Obese Diabetic db/db Mice
- Repression of Fat-Dependent Intestinal Apo A-IV mRNA Abundance by Medium Chain Triacylglycerols and Proteins, and Elevation by Carbohydrates of Fat-Dependent Apo A-IV Transport in Suckling Rat Pups.
- A Comparison of the Lipid-lowering Effects of Four Different n-3 Highly Unsaturated Fatty Acids in HepG2 Cells