Superiority of Dietary Safflower Oil over Olive Oil in Lowering Serum Cholesterol and Increasing Hepatic mRNAs for the LDL Receptor and Cholesterol 7α-Hydroxylase in Exogenously Hypercholesterolemic (ExHC) Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The exogenously hypercholesterolemic (ExHC) rat is a strain segregated from SD rats with a high response to dietary cholesterol. To understand the underlying mechanism(s) for this hypercholesterolemia, the interactive effects of dietary fatty acid and the susceptibility of rats to dietary cholesterol on the serum cholesterol concentration and hepatic mRNA abundance of the low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (7α-hydroxylase) and 3-hydroxyl-3methyl-glutaryl (HMG) CoA reductase were examined. Both strains were fed on a diet supplemented with 10% each of olive, safflower or coconut oil with or without the addition of 1% cholesterol for one week. The ExHC rats fed on olive, safflower and coconut oil in combination with cholesterol respectively resulted in a 3.5-, 2.0-and 2.1-fold higher serum cholesterol concentration than that in the animals fed on the corresponding dietary fats without any supplementation of cholesterol (p<0.01 by dietary cholesterol or type of fat). The dietary cholesterol dependent-elevation of serum cholesterol in the SD rats was less than 1.5-fold (p<0.01) and there was no dietary fat effect. The ExHC rats fed on the safflower oil-containing diet supplemented with cholesterol resulted in a higher mRNA abundance of the LDL receptor and 7α-hydroxylase than in the corresponding fat-fed rats without cholesterol (p<0.05). There was no dietary cholesterol-dependent change of mRNA abundance in either strain fed on olive or coconut oil, except for a decreased abundance of HMG CoA reductase mRNA in the olive oil-fed ExHC rats and coconut oil-fed Sprague-Dawley (SD) rats (p<0.05). These results indicate that the hepatic mRNA abundance of the LDL receptor and of 7α-hydroxylase depended on the dietary combination of cholesterol and a fatty acid and suggest that a linoleic acid-rich diet may alleviate exogenous hypercholesterolemia by activating the process involved in the hepatic uptake and biliary excretion of serum cholesterol.

• 社団法人日本農芸化学会の論文
• 2000-06-23

著者

• NAGAO Koji

  Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University

• SATO Masao

  Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University

• IMAIZUMI Katsumi

  Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University

• Nagao K

  School Of Medicine And Center For Aids Research Kumamoto University

• Sugano M

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Sugano M

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Imaizumi Katsumi

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Kyushu University

• Imaizumi Katsumi

  Lab. Of Nutrition Chemistry Div. Of Bioresource And Bioenvironmental Sciences Graduate School Kyushu

• Imaizumi Katsumi

  Lab. Of Nutrition Chemistry Fac. Of Agriculture Graduate School Of Kyushu Univ.

• Imaizumi K

  Kyushu Univ. Fukuoka Jpn

• Imaizumi Katsumi

  Laboratory Of Nutrition Chemistry Faculty Of Bioresources And Bioenvironmental Sciences Graduate Sch

• Sakono M

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University

• Yoshida S

  Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer

• Yoshida S

  Kyoto Univ. Kyoto Jpn

• Sugano M

  Kumamoto Prefectural Univ. Kumamoto Jpn

• Sugano Michihiro

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sugano Michihiro

  Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto

• Sugano Michihiro

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• YOSHIDA Susumu

  Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate S

• Nagao Koji

  Laboratory Of Nutrition Biochemistry Faculty Of Agriculture Saga University

• Nagao Koji

  Department Of Applied Biological Sciences Saga University

• Nagao Koji

  Laboratory Of Nutrition Biochemistry Department Of Applied Biological Sciences Saga University

• Yoshida S

  Kyoto Univ. Kyoto‐shi Jpn

• Nagao Kazuhiko

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Imaizumi Katsumi

  Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture

• Imaizumi Katsumi

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• Imaizumi Katsumi

  Laboratory Of Nutrition Chemistry Department Of Food Science And Technology School Of Agriculture (4

• Sugano M

  Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K

• Yoshida S

  Graduate School Of Informatics Kyoto University

• Sakano Masafumi

  Department Of Applied Chemstry Graduate School Of Engineering Kyushu University Hakozaki

• Imaizumi K

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University

• Sato Masao

  Laboratory Of Nutrition Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate Sch

• Sato Masao

  Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture

• Yoshida Susumu

  Laboratory Of Nutrition Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate Sch

• Imaizumi Katsumi

  Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University

関連論文

• Physiological Functions of iso-type Short-Chain Fatty Acid and Omega 3 Polyunsaturated Fatty Acids Containing Oil in Obese OLETF Rats
• Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
• Structured Triacylglycerol Containing Medium-Chain Fatty Acids in sn-1(3) Facilitates the Absorption of Dietary Long-Chain Fatty Acids in Rats
• Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
• Effects of Dietary Fats and Curcumin on IgE-Mediated Degranulation of Intestinal Mast Cells in Brown Norway Rats
• Effects of Glyco- and Tauro-Cholic and Chenodeoxycholic Acids on Lymphatic Absorption of Micellar Cholesterol and Sitosterol in Rats
• Effects of Xylooligosaccharides on Blood Glucose, Serum and Liver Lipids and Cecum Short-chain Fatty Acids in Diabetic Rats(Food & Nutrition)
• Influence of Saturated and Polyunsaturated Egg Yolk Phospholipids on Hyperlipidemia in Rats(Food & Nutrition)
• Comparison of Effects of Dietary Unesterified and Esterified Plant Sterols on Cholesterol Absorption in Rats
• Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
• Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
• Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats(Food & Nutrition Science)
• Intestinal Absorbability of Wheat Allergens, Subunits of a Wheat α-Amylase Inhibitor, Expressed by Bacteria(Food & Nutrition Science)
• Concentration of Serum Lipids and Aortic Lesion Size in Female and Male Apo E-Deficient Mice Fed Docosahexaenoic Acid
• Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats
• Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
• Prevention of Peroxidative Stress in Rats Fed on a Low Vitamin E-containing Diet by Supplementing with a Fermented Bovine Milk Whey Preparation : Effect of Lactic Acid and β-Lactoglobulin on the Antiperoxidative Action
• Folimycin (concanamycin A) and Bafilomycin A_1, Inhibitors Specific for V-ATPase,Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins
• Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intra-cellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus
• Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols: Comparison with Wistar Rats
• Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose: Comparison with Wistar Rats
• Fattiviracin A1, a Novel Antiviral Agent Produced by Streptomyces microflavus Strain No. 2445 II. Biological Properties
• The 9cis, 11trans, 13cis Isomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells
• S-Propyl-Cysteine Sulfoxide and DL-Methionine Sulfoxide Inhibit the Secretion of Apolipoprotein B100 and Lipids in HepG2 Cells
• Induction of Atherosclerosis in Brown Norway Rats by Immunization with Ovalbumin
• Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D
• Effect of Phytate in Soy Protein on the Serum and Liver Cholesterol Levels and Liver Fatty Acid Profile in Rats(Food & Nutrition Science)
• Choleseterol Supplementation Attenuates the Hypocholesterolemic Effect of Rice Bran Oil in Rats
• Propionate Enhances Synthesis and Secretion of Bile Acids in Primary Cultured Rat Hepatocytes via Succinyl CoA
• Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats
• Dietary Effect of Tocopherols and Tocotrienols on the Immune Function of Spleen and Mesenteric Lymph Node Lymphocytes in Brown Norway Rats
• Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
• Effect of Unsaturated Fatty Acids and α-Tocopherol on Immunoglobulin Levels in Culture Medium of Rat Mesenteric Lymph Node and Spleen Lymphocytes^1
• Effect of Unsaturated Fatty Acids and Antioxidants on Immunoglobulin Production by Mesenteric Lymph Mode Lymphocytes of Sprague-Dawley Rats
• Effects of n-3 Polyunsaturated Fatty Acids and Lectins on Immunoglobulin Production by Spleen Lymphocytes of Sprague-Dawley Rats
• Free Bile Acids Inhibit IgE Production by Mouse Spleen Lymphocytes Stimulated by Lipopolysaccharide and Interleukins
• Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells
• Differential Effect of Walnut Oil and Safflower Oil on the Serum Cholesterol Level and Lesion Area in the Aortic Root of Apolipoprotein E-deficient Mice(Food & Nutrition Science)
• Effects of Feeding Oyster, Crassostrea gigas, on Serum and Liver Lipid Levels in Rats
• Protection Against the Diabetogenic Effect of Feeding tert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin
• Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
• Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
• Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
• Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
• Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 II. Physico-chemical Properties and Structure Elucidation
• Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 I. Taxonomy, Fermentation, Isolation and Biological Activities
• Conjugated Fatty Acids in Food and Their Health Benefits
• Effect of Dietary Fats and Sesamin on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
• Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats
• Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats
• Adjuvant Activity of Synthetic Cationic Amphiphiles for Production of IgG Antibody in Sprague Dawley Rats
• Systemic Release of Mucosal Mast-cell Protease in Primed Brown Norway Rats after Feeding with β-Lactoglobulin
• Combined Effects of Dietary Protein Type and Fat Level on the Body Fat-Reducing Activity of Conjugated Linoleic Acid (CLA) in Rats
• Feeding Unsaponifiable Compounds from Rice Bran Oil Does Not Alter Hepatic mRNA Abundance for Cholesterol Metabolism-related Proteins in Hypercholesterolemic Rats
• Superiority of Dietary Safflower Oil over Olive Oil in Lowering Serum Cholesterol and Increasing Hepatic mRNAs for the LDL Receptor and Cholesterol 7α-Hydroxylase in Exogenously Hypercholesterolemic (ExHC) Rats
• Isomer-Specific Anti-Obese and Hypolipidemic Properties of Conjugated Linoleic Acid in Obese OLETF Rats
• Short-Term Feeding of Conjugated Linoleic Acid Does Not Induce Hepatic Steatosis in C57BL/6J Mice
• Alleviation of Fatty Liver by α-Linolenic Acid
• Purification of Conjugated Linoleic Acid Isomers through a Process Including Lipase-catalyzed Selective Esterification(Biochemistry & Molecular Biology)
• Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats
• Comparison of the Effects of Triacylglycerol-CLA and Free Fatty Acid-CLA on Hepatic Lipid Metabolism in OLETF Obese Rats
• Antiviral Activity of Fattiviracin FV-8 against Human Immunodeficiency Virus Type 1 (HIV-1)
• Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB_4 Production by Peritoneal Exudate Cells of Rats
• Development of Assay System for Immunoglobulin Production Regulatory Factors using Whole Cell Cultures of Mouse Splenocytes
• Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
• Dietary Effect of Guar Gum and its Partially Hydrolyzed Product on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
• Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
• Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
• Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
• Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
• Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
• Inhibition by Dietary Tea Polyphenols of Chemical Mediator Release from Rat Peritoneal Exudate Cells
• Effect of Dietary Antioxidants on Serum Lipid Contents and Immunoglobulin Productivity of Lymphocytes in Sprague-Dawley Rats
• Stimulating Effect of Xanthene Dyes on Immunoglobulin Produced in vitro by Rat Spleen Lymphocytes
• Effect of Vegetable Extracts on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats
• Effect of Reaction Temperature on the Determination of Rat Serum IgE by the Avidin-Biotin Method
• Measurement of Total and Food Component-Specific IgA in Human Saliva
• Effect of Oxidized Cholesterol on Age-associated Changes to Immune Parameters in Spleen Lymphocytes and Peritoneal Exudate Cells Derived from Rats
• Cytotoxicity and Suppression of Immunoglobulin Production against Human Namalwa Cells Caused by Oxidized Cholesterol
• Effect of Natural Food Colorings on Immunoglobulin Production in Vitro by Rat Spleen Lymphocytes
• Inhibition of Immunoglobulin Production in Human Namalwa Cells and Rat Spleen Lymphocytes by Bile Acid
• Diversity in the Incorporation into Tissue Phospholipids and Effects on Eicosanoid Production of trans-Monoene Fatty Acid in Rats Fed with Different Dietary Proteins
• Measurement of antigen-specific antibodies in human serum and saliva by multigen antigen simulaneous test
• Hydrolysis of Micellar Phosphatidylcholine Accelerates Cholesterol Absorption in Rats and Caco-2 Cells
• Effects of Rat Milk on the Secretion of Cholesterol and Bile Acids from Primary Monolayer Culture of Hepatocytes of Rat Pups(Food & Nutrition)
• Modulation by Casein and Soybean Protein Amino Acid Mixtures of Insulin- and Glucagon-dependent Linoleic Acid Desaturation in Primary-cultured Rat Hepatocytes
• Effect of Antigen Dose on Induction of β-Lactoglobulin-specific IgG and IgE in Brown Norway Rats
• Effects of Dietary Palm Oil and Tocotrienol Concentrate on Plasma Lipids, Eicosanoid Productions and Tissue Fatty Acid Compositions in Rats(Food & Nutrition)
• Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats
• Preparation of Antiserum against Rat Δ6-Desaturase and Its Use to Evaluate the Desaturase Protein Levels in Rats Treated with Gemfibrozil, a Ligand for Peroxisome Proliferator-activated Receptor α(Food & Nutrition Science)
• Dietary Pine Bark Extract Reduces Atherosclerotic Lesion Development in Male ApoE-Deficient Mice by Lowering the Serum Cholesterol Level
• Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
• Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
• Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats
• Physiological Effects of Dietary PIPS Soybean-Derived Phospholipid in Obese Zucker (fa-fa) Rats
• The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells
• Effect of Vaccinium ashei reade Leaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats
• Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
• Effect of Vaccinium ashei reade Leaf Extracts on Lipid Metabolism in Obese OLETF Rats
• Effects of Lotus Root (the Edible Rhizome of Nelumbo nucifera) on the Deveolopment of Non-Alcoholic Fatty Liver Disease in Obese Diabetic db/db Mice

もっと見る 閉じる

スポンサーリンク