Effects of n-3 Polyunsaturated Fatty Acids and Lectins on Immunoglobulin Production by Spleen Lymphocytes of Sprague-Dawley Rats
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概要
- 論文の詳細を見る
We examined the effects of n-3 polyunsaturated fatty acid (PUFA), such as α-linolenic (α-LA), eicosapentaenoic (EPA), and docosahexaenoic acid (DHA) on immunoglobulin (Ig) production by spleen lymphocytes of Sprague-Dawley rats. n-3 polyunsaturated fatty acid (PUFA) strongly inhibited the production of IgA and IgM and that of IgG weakly at 100 μM. When the lymphocytes were treated with n-3 PUFA in the presence of other inhibitory biomaterials such as lectins, some PUFA attenuated their inhibitory effect on Ig production. In the presence of concanavalin A (ConA), all n-3 PUFA attenuated the inhibitory effect of ConA on the production of IgM or IgG but increased its inhibition of IgA synthesis. Thus, the interaction of n-3 polyunsaturated fatty acid and lectins in spleen interfere with each other or the expression of Ig production regulating activity.
- 社団法人日本農芸化学会の論文
- 1996-06-23
著者
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Sugano M
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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SUGANO Michihiro
Laboratory of Food Chemistry, Department of Food Science and Technology, Faculty of Agriculture (46-
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Sakono M
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
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Lee Bong-hee
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Lee Bong-hee
韓国
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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Lim B
Department Of Life Science Konkuk University
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Lim Beong
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture 46-09 Ky
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Sugano Michihiro
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sugano Michihiro
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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HUNG Pham
九州大学農学部食糧化学教室
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Hung Pham
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra
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HUNG Pham
Laboratory of Food Science Department of Food Science and Technology, Faculty of Agriculture, Kyushu
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TANIGUCHI Saburo
Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture, Kyush
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WATANABE Takashi
Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture 46-09,
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Lim Beong
Department Of Life Science Konkuk University
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Taniguchi Shun'ichiro
Dep. Of Molecular Oncology Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine
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Sugano M
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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Hung Pham
Laboratory Of Food Chemistry Graduate School Of Agriculture And Biological Sciences Osaka Prefecture
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Yamada K
Faculty Of Engineering Okayama University:(present Address)department Of Biotechnology And Life Scie
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Taniguchi S
Biotechnology Research Center Toyama Prefectural University
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Watanabe T
Shizuoka University
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Lim Beong
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Taniguchi Shin-ichi
Department Of Molecular Oncology Institute On Aging And Adaptation Shinshu University Graduate Schoo
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Watanabe T
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture Kyushu U
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Watanabe Takashi
Laboratory of Biomass Conversion, RISH, Kyoto University
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