Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
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概要
- 論文の詳細を見る
The structure-activity relationship of allergy enhancing and suppressing factors in foodstuffs was summarized in this text. Polyunsaturated fatty acids (PUFA) enhance allergic response by enhancing IgE production and by suppressing production of other antibodies in rat lymphocytes. Because the expression of IgE production enhancing activity was inhibited by lipophilic antioxidants, lipid oxidation reaction seems to have participated in the activity. Xanthene dyes, a group of synthetic dyes, also exert IgE production enhancing effect, and the activity is dependent on the degree of halogenation. On the other hand, PUFA exert anti-allergic effect by suppressing the release of chemical mediators from rat peritoneal exudate cells, and the activity becomes stronger with the increase in the number of double bonds. In addition, antioxidants such as tea polyphenols (TP) and flavonoids exert anti-allergic effect mainly due to the suppression of chemical mediator release. Histamine release suppressing activity is observed in triphenol derivatives, but not in diphenols. On the contrary, LTB4 release suppressing activity is observed in mono and diphenolic derivatives with antioxidative activity. These results suggest that various food components have immunoregulatory activity and that optimization of their intake is desirable.
- 社団法人 日本食品科学工学会の論文
- 1999-02-01
著者
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Sugano Michihiro
Faculty of Agriculture, Kyushu University
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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TACHIBANA Hirofumi
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Tachibana H
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
九州大学 農学部生物機能化学食糧化学
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Tachibana Hirofumi
Graduate School Of Genetic Resources Technology Kyushu University
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Sugano M
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Sugano M
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sakono M
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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Sugano M
Kumamoto Prefectural Univ. Kumamoto Jpn
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Sugano Michihiro
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sugano Michihiro
Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto
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Sugano Michihiro
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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NISHIYAMA Kazuo
Department of Pharmacology, Kitasato University School of Medicine
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Nonaka Masahiko
Food Research & Development Laboratories Ajinomoto Co. Inc.
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MATSUO Noritaka
Department of Biochemistry, Oita Medical University
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Tachibana Hirofumi
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Tachibana Hirofumi
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Sugano M
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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Nakajima Masatoshi
Department Of Applied Biological Chemistry University Of Tokyo
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Nakayama M
Dept. Biol. Sci. Fac. Biosci. Biotechnol. Tokyo Inst. Technol.
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Nonaka M
Kyushu Univ. Fukuoka Jpn
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Nonaka M
Department Of Applied Biological Chemistry The University Of Tokyo
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Nishiyama Kazuo
Department Of Biological Resource Sciences Miyazaki University
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Tian Huaize
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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TACHIBANA Hirofumi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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