Free Bile Acids Inhibit IgE Production by Mouse Spleen Lymphocytes Stimulated by Lipopolysaccharide and Interleukins
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概要
- 論文の詳細を見る
The interaction of IL-4, IL-5, and free bile acids with the immunoglobulin production by mouse spleen lymphocytes was studied to examine their immunoregulatory activity. In the absence of lipopolysaccharide (LPS), IL-4 enhanced the IgE and IgG production significantly and the IgA production weakly, but not the IgM production. On the other hand, IL-5 had an inhibitory tendency on the IgE and IgA production, though not significantly. In the presence of LPS, both IL-4 and IL-5 significantly enhanced the IgE production by mouse splenic lymphocytes. When the lymphocytes were cultured with the physiological concentration of free bile acids (10μM) and LPS for 3 days, chenodeoxycholic acid inhibited the IgE production, but cholic and deoxycholic acids did not. In the presence of lL-4 or IL-5, these bile acids cancelled the stimulatory effects of interleukins and rather significantly inhibited the IgE production. These results suggest that these free bile acids act as an anti-allergic agent.
- 社団法人日本農芸化学会の論文
- 1995-04-23
著者
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Sugano M
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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SUGANO Michihiro
Laboratory of Food Chemistry, Department of Food Science and Technology, Faculty of Agriculture (46-
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Sakono M
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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Lim Ou
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture Kyushu U
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Sugano Michihiro
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sugano Michihiro
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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HUNG Pham
九州大学農学部食糧化学教室
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Hung Pham
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra
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HUNG Pham
Laboratory of Food Science Department of Food Science and Technology, Faculty of Agriculture, Kyushu
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YOSHIMURA Kazunari
Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture, Kyush
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TANIGUCHI Saburo
Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture, Kyush
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WATANABE Takashi
Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture 46-09,
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Taniguchi Shun'ichiro
Dep. Of Molecular Oncology Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine
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Sugano M
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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Hung Pham
Laboratory Of Food Chemistry Graduate School Of Agriculture And Biological Sciences Osaka Prefecture
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Taniguchi S
Biotechnology Research Center Toyama Prefectural University
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Watanabe T
Shizuoka University
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Taniguchi Shin-ichi
Department Of Molecular Oncology Institute On Aging And Adaptation Shinshu University Graduate Schoo
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Watanabe T
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture Kyushu U
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Watanabe Takashi
Laboratory of Biomass Conversion, RISH, Kyoto University
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