PREPARATION OF USEFUL SYNTHETIC INTERMEDIATES OF TAXOL ANALOGS, CYCLOOCTENONE DERIVATIVES
スポンサーリンク
概要
- 論文の詳細を見る
Stereoselective syntheses of ω-(α-bromoketo) octanals and nonanal with oxygenated functions and formation of the corresponding eight-membered carbocyclic aldols by subsequent samarium(II)-mediated cyclization are demonstrated. Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the above aldols.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
-
Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
-
Yamada K
Univ. Tokyo Tokyo
-
MUKAIYAMA Teruaki
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT)
-
Mukaiyama Teruaki
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
TOZAWA Takashi
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
-
Yamada K
Department Of Applied Molecular Chemistry College Of Industrial Technology Nihon University
-
Tozawa Takashi
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
SAITOH Katsuyuki
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
-
Yamada K
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Yamada K
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
-
Saitoh Katsuyuki
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Yamada Koji
Deparment Of Food Science And Technology Faculty Of Agriculture Kyushu University
関連論文
- Constitutively Active STAT5A and STAT5B In Vitro and In Vivo: Mutation of STAT5 Is Not a Frequent Cause of Leukemogenesis
- Diamond Film Formation by OH Radical Injection from Remote Microwave H_2/H_2O Plasma into Parallel-Plate RF Methanol Plasma
- Synthesis of Diamond Using RF Magnetron Methanol Plasma Chemical Vapor Deposition Assisted by Hydrogen Radical Injection
- The Development of a Computational Environment for Cellular Automata(Automata and Formal Language Theory)
- Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
- Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
- Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats
- Dietary Effect of Tocopherols and Tocotrienols on the Immune Function of Spleen and Mesenteric Lymph Node Lymphocytes in Brown Norway Rats
- Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
- Effect of Unsaturated Fatty Acids and α-Tocopherol on Immunoglobulin Levels in Culture Medium of Rat Mesenteric Lymph Node and Spleen Lymphocytes^1
- Effect of Unsaturated Fatty Acids and Antioxidants on Immunoglobulin Production by Mesenteric Lymph Mode Lymphocytes of Sprague-Dawley Rats
- Effects of n-3 Polyunsaturated Fatty Acids and Lectins on Immunoglobulin Production by Spleen Lymphocytes of Sprague-Dawley Rats
- Free Bile Acids Inhibit IgE Production by Mouse Spleen Lymphocytes Stimulated by Lipopolysaccharide and Interleukins
- Feasibility of Induction Chemotherapy Using Bronchial Arterial Infusion for Locally Advanced Non-Small Cell Lung Cancer : A Pilot Study
- Comparative Study on the Modulation of IgE and Cytokine Production by Phellinus linteus Grown on Germinated Brown Rice, Phellinus Linteus and Germinated Brown Rice in Murine Splenocytes
- Middle-Colic Artery Aneurysm Associated with Segmental Arterial Mediolysis, Successfully Managed by Transcatheter Arterial Embolization : Report of a Case
- Effect of Dietary Fats and Sesamin on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
- Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats
- Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats
- Tocotrienol Levels in Various Tissues of Sprague-Dawley Rats after Intragastric Administration of Tocotrienols(Food & Nutrition Sience)
- Dietary Effect of α-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats
- Tissue-specific Distribution of Genistein, Daidzein and Bisphenol A in Male Sprague-Dawley Rats after Intragastric Administration
- Adjuvant Activity of Synthetic Cationic Amphiphiles for Production of IgG Antibody in Sprague Dawley Rats
- Changes in Specificities of Human Monoclonal Antibodies by Introduction of Drug-resistance Gene into Hybridomas(Biological Chemistry)
- Stimulation by 2-Mercaptoethanol and Alcohols of Protease in Antarctic Krill, Euphausia superba, at Low Temperatures(Biological Chemistry)
- Simultaneous Determination of Isoflavones and Bisphenol A in Rat Serum by High-performance Liquid Chromatography Coupled with Coulometric Array Detection
- Voltage Dependency in Coulometric Analysis of Tea Polyphenols and Isoflavones in Foodstuffs
- Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats
- Dietary Effects of Porphyran from Porphyra yezoensis on Growth and Lipid Metabolism of Sprague-Dawley Rats
- Effect of Dietary Fiber on the Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats(Food & Nutrition Science)
- Effect of Dietary cabbage Fermentation Extract and Young Barley Leaf Powder on Immune Function of Sprague-Dawley Rats
- Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes
- Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB_4 Production by Peritoneal Exudate Cells of Rats
- Development of Assay System for Immunoglobulin Production Regulatory Factors using Whole Cell Cultures of Mouse Splenocytes
- Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
- Optimization of Estrogenic Activity Detection Method Using Human Breast Cancer MCF-7 Cells
- Dietary Effect of Guar Gum and its Partially Hydrolyzed Product on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
- Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
- Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
- Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
- Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
- Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
- Inhibition by Dietary Tea Polyphenols of Chemical Mediator Release from Rat Peritoneal Exudate Cells
- Effect of Dietary Antioxidants on Serum Lipid Contents and Immunoglobulin Productivity of Lymphocytes in Sprague-Dawley Rats
- Stimulating Effect of Xanthene Dyes on Immunoglobulin Produced in vitro by Rat Spleen Lymphocytes
- Effect of Vegetable Extracts on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats
- Effect of Reaction Temperature on the Determination of Rat Serum IgE by the Avidin-Biotin Method
- Effects of Phenyl Compounds on Proliferation and IgM Production of Human-Human Hybridoma HB4C5 Cells Cultured in Serum-free Medium(Food & Nutrition)
- Effect of Immunoglobulin Production Stimulating Factors in Foodstuffs on Immunoglobulin Production of Human Lymphocytes(Food & Nutrition)
- Screening of Immunoglobulin Production Stimulating Factor (IPSF) in Foodstuffs Using Human-human Hybridoma HB4C5 Cells(Food & Nutrition)
- A Novel Iodine-bridged Piano-stool Iron Complex : Crystal Structure and Electronic State
- Measurement of Total and Food Component-Specific IgA in Human Saliva
- Angiocentric Immunoproliferative Lesion of the Lung
- Analysis of MAGE-3 derived synthetic peptide as a human lung cancer antigen recognized by cytotoxic T lymphocytes
- Decrease of β-cells and Increase of α-cells in a Diabetic Patient with Mitochondrial DNA 3243 (A→G) Mutation
- Electroluminescence of Poly Bis(p-propoxyphenyl)Silane from Double-Layer Device with 8-Hydroxyquinoline Aluminum
- Efficient Intermolecular Energy Transfer between Polysilanes Revealed by Time-Resolved Photoluminescence
- Detection of Plastic Deformation and Fatigue Damage in Pressure Vessel Steel by Leakage Magnetic Flux Sensors
- Asymmetric Allylation of Carbonyl Compounds with Tartrate-Modified Chiral Allylic Tin Reagents
- Asymmetric Allylation of Aromatic Aldehydes Using Chiral Allylic Tin Reagents
- Phase Transitions and Molecular Motions in Guanidinium-d_6 Trihalogenomercurates(II) [C(ND_2)_3]HgBr_3 and [C(ND_2)_3]HgI_3 as Investigated by Means of ^Br and ^I NQR and ^2H NMR
- Dynamic Property of H_2O in Layered VOPO_4・2H_2O Studied by Solid-State NMR
- Crystal Structure and Ionic Conduction Mechanism of AgHgSX (X=Br, I)
- Crystal Structure of High Temperature Phase and Ionic Conductivity Mechanism of CuHgSX (X=Cl, Br)
- New Anionic Conductor KSbF_4 with Fluorite Structure
- New Lithium Ion Conductor Li_3InBr_6 Studied by ^7Li NMR
- Cation Diffusion in MGaBr_4 (M = Li, Cu, and Ag) Studied by ^7Li, ^Cu, and ^Ga NMR, ^BrNQR, and Conductivity
- NQR, NMR, and DSC Study of [NH_3 (CH_2) _3NH_3] CdBr_4
- Molecular Reorientation in AlBr_3・NH_3, as Studied by the ^Br Nuclear Quadrupole Resonance
- Role of Human Telomerase Reverse Transcriptase and Telomeric-repeat Binding Factor Proteins I and 2 in Human Hematopoietic Cells
- Below-Gap Spectroscopy of Undoped GaAs/AlGaAs Quantum Wells by Two-Wavelength Excited Photoluminescene
- Multiplication of Bovine Viruses in Hamster Lung HmLu-1 Cells Cultured in Protein-free Medium(Microbiology & Fermentation Industry)
- Development of a Protein-free Medium with Ferric Citrate Substituting Transferrin for the Cultivation of Mouse-Mouse Hybridomas(Food & Nutrition)
- Stimulation and Inhibition of Interferon-β Production of Human Diploid Fibroblasts by Foodstuffs(Food & Nutrition)
- Establishment and Characterization of Monoclonal Antibodies Against Bovine Ephemeral Fever Virus(Biological Chemistry)
- Proliferation-stimulating Activity of Detergents Having Oleic Acid Residues in Serum-free Culture of Mammalian Cells(Biological Chemistry)
- Production of DNA-breaking Substance after Treatment of Monophenols with Sodium Nitrite and then with Dimethyl Sulfoxide(Biological Chemistry)
- Purification and Some Properties of an Antibacterial Factor Derived from Bacillus subtilis FHC 402(Biological Chemistry)
- Deuterium Nuclear Magnetic Resonance Study of Lipophilic Chains in the C_E_3/Decane/Water Ternary System
- Conformational Dynamics of Alkyl Chains in the Lamellar Phase of a Nonionic Surfactant C_E_3 Studied by Deuterium Nuclear Magnetic Resonance
- PREPARATION OF USEFUL SYNTHETIC INTERMEDIATES OF TAXOL ANALOGS, CYCLOOCTENONE DERIVATIVES
- Construction of AB-Ring System of Taxane Framework by A-Ring Annulation Strategy : Synthesis of 1-Hydroxy-8,11,11-trimethylbicyclo-[5.3.1]undec-7-en-9-one by Way of Intramolecular Aldol Cyclization to Form the C1-C10 Bond
- Pleomorphic Carcinoma : Report of a Case with Massive Pleural Effusion and Asbestos Particles
- Establishment of an immortalized T-cell line from lung cancer tissue : phenotypic and functional analyses
- Effects of Fatty Acids on Accumulation and Secretion of Histamine in RBL-2H3 Cells and Leukotriene Release from Peritoneal Exudate Cells Isolated from Wistar Rats
- Changes of Blood Elements and the Circulatory System in Climbing
- Infuences of the Renal Lesions of Masugi Nephritis on Hematopoetic Functions and Effects of Chlorpromazine and Histamine on Masugi Nephritis
- The Role of Emitter States in Magnetotunneling through Double-Barrier Resonant-Tunneling Diodes at High Magnetic Fields
- Characteristic Phase Transition of [C_5H_5NH]SbBr_4Having a Hypervalent Bond Studied by Single Crystal X-Ray Diffraction and ^2HNMR
- Listeria-like Motion of Oil Droplets
- Morphological Change of Giant Vesicles Triggered by Dehydrocondensation Reaction
- Phase Transition and Electric Conductivity of ASnCl_3 (A = Cs and CH_3NH_3)
- Effects of Butyrate on Cell Cycle Progression and Polyploidization of Various Types of Mammalian Cells
- Response to : Coronary flow reserve : a new target for treating hypertension
- Production of Osmotically Labile Cells in Chlorella ellipsoidea C-27 and C-102 by Enzyme Treatment(Biological Chemistry)
- Formation of Eu2+ in SiO2-Al2O3 Glass During Thermal Treatment in Sol-Gel Process
- 2A1-E15 Studies on athletic ability of modular robot
- In vivo Corrosion and Tarnish of Dental Au-based and Ag-based Alloy Restorations
- Occurrence of the Spin-crossover Phenomenon of Assembled Complexes, Fe(NCX)_2(bpa)_2 (X = S, BH_3 ; bpa = 1,2-Bis(4-pyridyl)ethane) by Enclathrating Organic Guest Molecule
- Tunable Perovskite Semiconductor CH_3NH_3SnX_3 (X : Cl, Br, or I) Characterized by X-ray and DTA