Inhibition by Dietary Tea Polyphenols of Chemical Mediator Release from Rat Peritoneal Exudate Cells

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概要

• 論文の詳細を見る

• Male Wistar rats were given purified diets containing safflower (SAF), perilla (PER), or palm (PAL) oils with or without 1% tea polyphenols (TP) for 3 weeks, and chemical mediator releasing activity from rat peritoneal exudate cells (PEC) was measured. Histamine releasing activity was not influenced by TP, while histamine release and intracellular histamine content were significantly increased in the PAL-fed group. On the contrary, leukotriene B_4 (LTB_4) release was significantly lower in rats fed PER than in those fed SAF and PAL, and TP significantly decreased the release in all fat groups. TP also significantly inhibited the release of LTB_5,which was generated only in rats fed PER. TP significantly decreased the proportion of arachidonic acid (AA) in PEC in the SAF-fed group and that of eicosapentaenoic acid (EPA), the precursor of LTB_5 in the PER-fed group, but did not influence that of AA in the PAL-and PER-fed group. These results suggest that ingestion of TP improves type I allergic symptom through the inhibition of LT release though the inhibition by TP could not be totally explained by the reduction of substrate fatty acid.

• 社団法人日本農芸化学会の論文
• 2000-07-23

著者

• Yamada Koji

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• YAMADA Koji

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky

• Yamada Koji

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Sugano M

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Sugano M

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sakono M

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University

• Yazawa K

  九州大学 農学部生物機能化学食糧化学

• Ueyama T

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Sugano M

  Kumamoto Prefectural Univ. Kumamoto Jpn

• Sugano Michihiro

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sugano Michihiro

  Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto

• Sugano Michihiro

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• SUGANO Michihiro

  Department of Living Environment Science, Kumamoto Prefectural University

• YUNOKI Shinichi

  Laboratory of Food Science Department of Food Science and Technology, Faculty of Agriculture, Kyushu

• MORI Mitsuo

  Laboratory of Food Science, Department of Food Science and Technology, Faculty of Agriculture, Kyush

• Nonaka Masahiko

  Food Research & Development Laboratories Ajinomoto Co. Inc.

• Ozeki Makoto

  Research & Development Central Research Laboratories Taiyo Kagaku Co. Ltd.

• MATSUO Noritaka

  Department of Biochemistry, Oita Medical University

• SHOJI Kentaro

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource an

• UEYAMA Takashi

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource an

• YAMASHITA Kouhei

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource an

• Sugano M

  Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K

• Yamada K

  Faculty Of Engineering Okayama University:(present Address)department Of Biotechnology And Life Scie

• Nakajima Masatoshi

  Department Of Applied Biological Chemistry University Of Tokyo

• Nakayama M

  Dept. Biol. Sci. Fac. Biosci. Biotechnol. Tokyo Inst. Technol.

• Yamada K

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Nonaka M

  Kyushu Univ. Fukuoka Jpn

• Shoji K

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Matsuo N

  Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

• Uehara Takashi

  School Of Allied Health Sciences Osaka University Faculty Of Medicine

• Katayama Y

  Graduate School Of Bio-applications And Systems Engineering Tokyo University Of Agriculture And Tech

• Mori M

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Yunoki Shinichi

  Department Of Bioscience And Biotechnology Division Of Bioenvironmental Sciences Graduate School Of

• Nonaka M

  Department Of Applied Biological Chemistry The University Of Tokyo

• Sugano Michihiro

  Deparment Of Food Science And Technology Faculty Of Agriculture Kyushu University

• Yamada Koji

  Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Mori Mitsuo

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Science, Graduate School Kyushu University

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