Construction of AB-Ring System of Taxane Framework by A-Ring Annulation Strategy : Synthesis of 1-Hydroxy-8,11,11-trimethylbicyclo-[5.3.1]undec-7-en-9-one by Way of Intramolecular Aldol Cyclization to Form the C1-C10 Bond
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概要
- 論文の詳細を見る
Construction of the AB-ring system of the taxane framework via an A-ring annulation strategy was demonstrated by base-mediated intramolecular aldol reaction of (Z)-2,2-dimethyl-3-(1-methyl-2-oxopropylidene)cyclooctanone, affording the title compound, 1-hydroxy-8,11,11-trimethylbicyclo[5.3.1]undec-7-en-9-one. A cyclization precursor, the tetra-substituted (Z)-alkene, was prepared from the corresponding cyclooctanone derivative, 3-[(α, α-dimethylbenzyl)dimethylsiloxy]-2,2-dimethylcyclooctanone via a bicyclic α, β-unsaturated lactone intermediate.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Yamada K
Univ. Tokyo Tokyo
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MUKAIYAMA Teruaki
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT)
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Mukaiyama Teruaki
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Yamada K
Department Of Applied Molecular Chemistry College Of Industrial Technology Nihon University
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IWADARE Hayato
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
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Yamada K
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Iwadare Hayato
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Yamada K
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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Yamada Koji
Deparment Of Food Science And Technology Faculty Of Agriculture Kyushu University
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