Tissue-specific Distribution of Genistein, Daidzein and Bisphenol A in Male Sprague-Dawley Rats after Intragastric Administration
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概要
- 論文の詳細を見る
A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at 0h and levels subsequently dropped and then increased again, reaching the initial level at 24h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24h. Bisphenol A and equol in the MLN was detectable at 6 to 24h and 24h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6h. Bisphenol A was detected in the epididymis at 6 to 12h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.
- 2005-05-01
著者
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安田 伸
東海大学農学部バイオサイエンス学科
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安田 伸
九州大学大学院農学研究院生物機能科学部門生物機能化学講座食糧化学教室
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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TACHIBANA Hirofumi
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Tachibana H
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
九州大学 農学部生物機能化学食糧化学
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Tachibana Hirofumi
Graduate School Of Genetic Resources Technology Kyushu University
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Yasuda Shin
Tokai Univ. Kumamoto Jpn
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Okabe Masaaki
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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YASUDA Shin
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and
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Yasuda Shin
School Of Agriculture Tokai University
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WU Po-Sheng
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and
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Tachibana Hirofumi
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Tachibana Hirofumi
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Yasuda Shin
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Yasumoto K
Second Department Of Surgery School Of Medicine University Of Occupational And Environmental Health
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Oji Mariko
Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric
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Wu Po-sheng
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Wu Po-sheng
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tian Huaize
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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TACHIBANA Hirofumi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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安田 伸
東海大・農・バイオ
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