Adjuvant Activity of Synthetic Cationic Amphiphiles for Production of IgG Antibody in Sprague Dawley Rats

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概要

• 論文の詳細を見る

• 12GP2 and 14GP2, synthetic cationic amphiphiles, were examined in Sprague-Dawley rats for their adjuvant activity with ovalbumin (OVA) as antigen. Findings were compared with the activity of complete Freund’s adjuvant (CFA) and aluminum hydroxide (Alum). Both amphiphiles induced OVA specific IgG comparable to the conventional adjuvants CFA or Alum, and total IgG levels of 12GP2 and 14GP2 groups were lower than the levels of other conventional adjuvants or with no adjuvant. Induction of OVA specific IgA and IgM were not observed. Examination of the effect of these adjuvants on T cell population of spleen lymphocytes showed that. CD4+/CD8+ ratio, CD4+ populations and CD8+ populations in rats immunized with the four adjuvants differed. Therefore, these adjuvants have different mechanisms for exerting immunoadjuvant activities.

• 社団法人　日本食品科学工学会の論文
• 2001-02-01

著者

• Yamada Koji

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• YAMADA Koji

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky

• Yamada Koji

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Sugano M

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Sugano M

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sugano Michihiro

  Kumamoto Prefecture University

• SUGANO Michihiro

  Laboratory of Food Chemistry, Department of Food Science and Technology, Faculty of Agriculture (46-

• Sakono M

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University

• Yazawa K

  九州大学 農学部生物機能化学食糧化学

• Kanegae H

  Fukuoka Industrial Technology Center

• Kanegae Hiroshi

  Fukuoka Industrial Technology Center

• Akao Tetsuyuki

  Fukuoka Industrial Technology Center

• Sato M

  Laboratory Of Nutrition Chemistry Faculty Of Bioresources And Bioenvironmental Sciences Graduate Sch

• SUGANO Michihiro

  Prefectural University of Kumamoto

• Sugano M

  Kumamoto Prefectural Univ. Kumamoto Jpn

• Sugano Michihiro

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sugano Michihiro

  Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto

• Sugano Michihiro

  Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K

• Sugano Michihiro

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• Nonaka Masahiko

  Food Research & Development Laboratories Ajinomoto Co. Inc.

• OKUMURA Shiro

  Fukuoka Industrial Technology Center

• MATSUO Noritaka

  Laboratory of Food Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School

• Sugano M

  Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K

• Yamada K

  Faculty Of Engineering Okayama University:(present Address)department Of Biotechnology And Life Scie

• Nakayama M

  Dept. Biol. Sci. Fac. Biosci. Biotechnol. Tokyo Inst. Technol.

• Yamada K

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Nonaka M

  Kyushu Univ. Fukuoka Jpn

• Matsuo N

  Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

• Sakono Masanobu

  Dep. Of Biochemistry And Applied Biosciences Fac. Of Agriculture Univ. Of Miyazaki

• Nonaka M

  Department Of Applied Biological Chemistry The University Of Tokyo

• Yamada Koji

  Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

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