Development of Assay System for Immunoglobulin Production Regulatory Factors using Whole Cell Cultures of Mouse Splenocytes
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概要
- 論文の詳細を見る
We tried to establish an assay system for screening and assessment of immunoregulatory factors using whole cell cultures of mouse splenocytes and found that splenic adhesive cells markedly increased immunogobulin (Ig) production of splenocytes. In the absence of adhesive cells, lipopolysaccharides, pokeweed mitogen, and phytohemagglutinin stimulated the production of IgA, IgG, and IgM in a class-dependent manner. Adhesive cells increased more markedly Ig production of splenocytes stimulated with these mitogens. When mouse splenocytes were cultured with milk proteins in the absence of adhesive cells, lactoferrin, β-lactoglobulin, α-casein, and β-casein stimulated IgA and IgG production. Adhesive cells increased IgA production of splenocytes stimulated with milk proteins, especially. These results suggest that the assay system is useful for assessment of Ig production-regulating factors.
- 社団法人日本農芸化学会の論文
- 2001-01-23
著者
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Sugano Michihiro
Faculty of Agriculture, Kyushu University
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Yamada Koji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Tachibana H
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
九州大学 農学部生物機能化学食糧化学
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Tachibana Hirofumi
Graduate School Of Genetic Resources Technology Kyushu University
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Sugano M
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Sugano M
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sugano Michihiro
Kumamoto Prefecture University
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Sakono M
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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SUGANO Michihiro
Prefectural University of Kumamoto
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Sugano M
Kumamoto Prefectural Univ. Kumamoto Jpn
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Sugano Michihiro
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
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Sugano Michihiro
Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto
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Sugano Michihiro
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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TACHIBANA Hirofumi
Division of Applied Biological Chemistry, Department ofBioscience and Biotechnology, Faculty of Agri
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YAMADA Koji
Division of Applied Biological Chemistry, Department ofBioscience and Biotechnology, Faculty of Agri
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TAKASUGI Mikako
Faculty of Human Life Science, Yamaguchi Prefectural University
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TAMURA Yuki
Division of Bioresource and Bioenvironmental Sciences, Graduate School of Kyushu University
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Tachibana Hirofumi
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Sugano M
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tamura Yuki
Division Of Bioresource And Bioenvironmental Sciences Graduate School Of Kyushu University
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Tanaka M
Faculty Of Human Life Science Yamaguchi Prefectural University
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Tian Huaize
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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TACHIBANA Hirofumi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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