Effect of Oxidized Cholesterol on Age-associated Changes to Immune Parameters in Spleen Lymphocytes and Peritoneal Exudate Cells Derived from Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of oxidized cholesterol on immune parameters were examined by using spleen lymphocytes and peritoneal exudate cells (PEC) derived from 5-week-(Young) and 9-month-old (Adult) rats. The immunoglobulin (Ig) G and IgM production was inhibited by oxidized cholesterol in the rats of both ages when lymphocytes were exposed to 30μg/ml of oxidized cholesterol for 24hr. The intracellular IgA level was also lowered by 30μg/ml of oxidized cholesterol, irrespective of age. In contrast, IgE production was significantly increased by the addition of 30μg/ml of oxidized cholesterol in only young lymphocytes. Moreover, oxidized cholesterol enhanced the intracellular histamine accumulation in only adult PEC, although the total histamine level produced by PEC was similar in the rats of both ages. These results thus suggest the possibility that oxidized cholesterol can have different effects on the age-related modulation of immune functions such as Igs production and histamine release.
- 社団法人日本農芸化学会の論文
- 2000-05-23
著者
-
Sugano Michihiro
Faculty of Agriculture, Kyushu University
-
YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
-
Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
-
Sugano M
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
-
Sugano M
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
-
Sakono M
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
-
Yazawa K
九州大学 農学部生物機能化学食糧化学
-
Osada K
Yakult Central Inst. Tokyo Jpn
-
Osada Kyoichi
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
-
Osada Kazuhiro
Laboratory Of Cellular Regulation Technology Graduate School Of Genetic Resources Technology Kyushu
-
Sugano M
Kumamoto Prefectural Univ. Kumamoto Jpn
-
Sugano Michihiro
Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto
-
Sugano Michihiro
Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto
-
Sugano Michihiro
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
-
NAKAMURA Shingo
Laboratory of Gene Expression, Wood Research Institute, Kyoto University
-
Osada Kazuhiro
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
-
MINEHIRA Kaori
Laboratory of Food Science, Kyushu University, School of Agriculture
-
INOUE Shinichiro
Laboratory of Food Science, Kyushu University, School of Agriculture
-
Sugano M
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
-
Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
-
Minehira Kaori
Laboratory Of Food Science Kyushu University School Of Agriculture
-
Nakamura Shingo
Laboratory Of Applied Life Science Faculty Of Agriculture And Life Science Hirosaki University
-
Inoue Shinichiro
Laboratory Of Food Science Kyushu University School Of Agriculture
-
Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
関連論文
- Hepatic Function and Lipid Metabolism Are Modulated by Short-term Feeding of Cholesterol Oxidation Products in Rats
- Cistanche salsa extract acts similarly to proteinbound polysaccharide-K (PSK) on various types of cell lines
- Immunomodulatory factors in Cistanche salsa
- Cistanche salsa extract induced apoptosis in the human Burkitt's lymphoma cell line Namalwa
- Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
- Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
- Increased Expression of Hypothalamic NADPH-Diaphorase Neurons in Mice with Iron Supplement
- Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1
- Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
- Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
- Leiomyoma Originating from the Extrapleural Tissue of the Chest Wall
- Dietary Effect of Tocopherols and Tocotrienols on the Immune Function of Spleen and Mesenteric Lymph Node Lymphocytes in Brown Norway Rats
- Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
- Effect of Unsaturated Fatty Acids and α-Tocopherol on Immunoglobulin Levels in Culture Medium of Rat Mesenteric Lymph Node and Spleen Lymphocytes^1
- Effect of Unsaturated Fatty Acids and Antioxidants on Immunoglobulin Production by Mesenteric Lymph Mode Lymphocytes of Sprague-Dawley Rats
- Effects of n-3 Polyunsaturated Fatty Acids and Lectins on Immunoglobulin Production by Spleen Lymphocytes of Sprague-Dawley Rats
- Free Bile Acids Inhibit IgE Production by Mouse Spleen Lymphocytes Stimulated by Lipopolysaccharide and Interleukins
- Comparative Study on the Modulation of IgE and Cytokine Production by Phellinus linteus Grown on Germinated Brown Rice, Phellinus Linteus and Germinated Brown Rice in Murine Splenocytes
- Production of Recombinant Human Monoclonal Antibody Using ras-Amplified BHK-21 Cells in a Protein-free Medium
- Dissimilarity in Fos and Jun Immunoreactivity in Hypothalamic Regions between Obese and Lean Zucker Rats
- Effect of Dietary Fats and Sesamin on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
- Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats
- Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats
- Clinicopathologic Significance of an Immunohistochemical Expression of p27 in Scirrhous Carcinoma of the Breast
- Tissue-specific Distribution of Genistein, Daidzein and Bisphenol A in Male Sprague-Dawley Rats after Intragastric Administration
- Adjuvant Activity of Synthetic Cationic Amphiphiles for Production of IgG Antibody in Sprague Dawley Rats
- Systemic Release of Mucosal Mast-cell Protease in Primed Brown Norway Rats after Feeding with β-Lactoglobulin
- Combined Effects of Dietary Protein Type and Fat Level on the Body Fat-Reducing Activity of Conjugated Linoleic Acid (CLA) in Rats
- Changes in Specificities of Human Monoclonal Antibodies by Introduction of Drug-resistance Gene into Hybridomas(Biological Chemistry)
- Stimulation by 2-Mercaptoethanol and Alcohols of Protease in Antarctic Krill, Euphausia superba, at Low Temperatures(Biological Chemistry)
- Simultaneous Determination of Isoflavones and Bisphenol A in Rat Serum by High-performance Liquid Chromatography Coupled with Coulometric Array Detection
- Voltage Dependency in Coulometric Analysis of Tea Polyphenols and Isoflavones in Foodstuffs
- Dietary Effects of Porphyran from Porphyra yezoensis on Growth and Lipid Metabolism of Sprague-Dawley Rats
- Effect of Dietary cabbage Fermentation Extract and Young Barley Leaf Powder on Immune Function of Sprague-Dawley Rats
- Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes
- Development of Assay System for Immunoglobulin Production Regulatory Factors using Whole Cell Cultures of Mouse Splenocytes
- Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
- Optimization of Estrogenic Activity Detection Method Using Human Breast Cancer MCF-7 Cells
- Dietary Effect of Guar Gum and its Partially Hydrolyzed Product on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
- Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
- Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
- Production of a Recombinant Human Monoclonal Antibody Using a Novel Hollow Fiber Bioreactor System
- Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
- Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
- Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
- Inhibition by Dietary Tea Polyphenols of Chemical Mediator Release from Rat Peritoneal Exudate Cells
- Effect of Dietary Antioxidants on Serum Lipid Contents and Immunoglobulin Productivity of Lymphocytes in Sprague-Dawley Rats
- Stimulating Effect of Xanthene Dyes on Immunoglobulin Produced in vitro by Rat Spleen Lymphocytes
- Effect of Vegetable Extracts on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats
- Effect of Reaction Temperature on the Determination of Rat Serum IgE by the Avidin-Biotin Method
- Effects of Phenyl Compounds on Proliferation and IgM Production of Human-Human Hybridoma HB4C5 Cells Cultured in Serum-free Medium(Food & Nutrition)
- Effect of Immunoglobulin Production Stimulating Factors in Foodstuffs on Immunoglobulin Production of Human Lymphocytes(Food & Nutrition)
- Screening of Immunoglobulin Production Stimulating Factor (IPSF) in Foodstuffs Using Human-human Hybridoma HB4C5 Cells(Food & Nutrition)
- Measurement of Total and Food Component-Specific IgA in Human Saliva
- Effect of Oxidized Cholesterol on Age-associated Changes to Immune Parameters in Spleen Lymphocytes and Peritoneal Exudate Cells Derived from Rats
- Cytotoxicity and Suppression of Immunoglobulin Production against Human Namalwa Cells Caused by Oxidized Cholesterol
- DNA-Breakage Inhibition by Bile Acids and Glycine
- Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema
- Surgical treatment for chest wall invasion due to the local recurrence of breast cancer
- Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B
- Effect of Natural Food Colorings on Immunoglobulin Production in Vitro by Rat Spleen Lymphocytes
- Inhibition of Immunoglobulin Production in Human Namalwa Cells and Rat Spleen Lymphocytes by Bile Acid
- Diversity in the Incorporation into Tissue Phospholipids and Effects on Eicosanoid Production of trans-Monoene Fatty Acid in Rats Fed with Different Dietary Proteins
- Measurement of antigen-specific antibodies in human serum and saliva by multigen antigen simulaneous test
- Combined Effects of Dietary Conjugated Linoleic Acid and Sesamin on Triacylglycerol and Ketone Body Production in Rat Liver
- Measurements of Mutagenic and Antimutagenic Activities of Bile Acids by Rec-assay
- Multiplication of Bovine Viruses in Hamster Lung HmLu-1 Cells Cultured in Protein-free Medium(Microbiology & Fermentation Industry)
- Development of a Protein-free Medium with Ferric Citrate Substituting Transferrin for the Cultivation of Mouse-Mouse Hybridomas(Food & Nutrition)
- Stimulation and Inhibition of Interferon-β Production of Human Diploid Fibroblasts by Foodstuffs(Food & Nutrition)
- Establishment and Characterization of Monoclonal Antibodies Against Bovine Ephemeral Fever Virus(Biological Chemistry)
- Proliferation-stimulating Activity of Detergents Having Oleic Acid Residues in Serum-free Culture of Mammalian Cells(Biological Chemistry)
- Production of Pentameric Hybrid Immunoglobulins Consisting of IgA and IgM(Biological Chemistry)
- Effect of Polysaccharides on Rheological Properties of Soy Protein Isolate Emulsion Gels
- Epinephrine-Oxidizing Activity in Calf Thymus Nucleosome
- Production of DNA-breaking Substance after Treatment of Monophenols with Sodium Nitrite and then with Dimethyl Sulfoxide(Biological Chemistry)
- Preparations of Histone and Nucleosome
- Effect of Dietary Sesamin on Metabolic Fate of an Exogenous Linolelaidic Acid in Perfused Rat Liver
- Effect of Antigen Dose on Induction of β-Lactoglobulin-specific IgG and IgE in Brown Norway Rats
- Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma
- Lung cancer-associated tumor antigens and the present status of immunotherapy against non-small-cell lung cancer
- Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers
- Resistance to gefitinib
- Trans Fatty Acids in Margarines Marketed in Eleven Countries
- Study of trans Fatty Acid Content in Commercial Foods in Japan: 4.Chocolate and Chocolate Confectioery 〔和文〕
- Relationship between Estrogen Receptor-Binding and Estrogenic Activities of Environmental Estrogens and Suppression by Flavonoids(Biochemistry & Molecular Biology)
- Surgical Outcome of an Anatomical Resection of Clinical Stage IA Non-Small Cell Lung Cancer Assisted with a Video-Thoracoscopy
- Mediastinal Metastasis from a Fibrolamellar Hepatocellular Carcinoma : Report of a Case
- Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis in Sprague-Dawley Rats Fed Saturated and Polyunsaturated Triacylglycerols and Diacylglycerols
- Gefitinib and a Ventriculo-Peritoneal Shunt to Manage Carcinomatous Meningitis from Non-Small-Cell Lung Cancer : Report of Two Cases
- Dietary Restriction Downregulates Free Radical and Lipid Peroxide Production : Plausible Mechanism for Elongation of Life Span
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Effects of Dietary Soybean Peptides on Hepatic Production of Ketone Bodies and Secretion of Triglyceride by Perfused Rat Liver
- Identification of a lung cancer antigen evading CTL attack due to loss of human leukocyte antigen (HLA) class I expression
- Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells
- Effect of Estrogens on the Interferon-γ Producing Cell Population of Mouse Splenocytes
- Increase of Immunoglobulin Productivity of Human-Human Hybridoma HB4C5 Cells by Histone(Biochemistry & Molecular Biology)
- Effects of Estrogenic Compounds on Immunoglobulin Production by Mouse Splenocytes(Analytical Biochemistry)
- Combined Effects of Dietary Conjugated Linoleic Acid and Sesamin on Triacylglycerol and Ketone Body Production in Rat Liver
- Balanced Intake of Polyunsaturated Fatty Acids for Health Benefits