Dissimilarity in Fos and Jun Immunoreactivity in Hypothalamic Regions between Obese and Lean Zucker Rats
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概要
- 論文の詳細を見る
The obese Zucker rat, whose genotype is transmitted in an autosomal recessive fashion, is an animal model widely used in the field of obesity. The expression of the nuclear transcription factors c-Fos and c-Jun in the paraventricular nucleus (PVN) and arcuate nucleus (ARC) of the hypothalamus of obese Zucker rats was studied using immunohistochemical methods. PVN and ARC in the hypothalamus are known as centers for the control of food intake. It was observed that the numbers of c-Fos-positive and c-Jun-positive neurons in these regions decreased in obese rats compared to lean rats, and that difference was more evident in the ARC than in the PVN which has to do with the regulation of body weight. The reduction in expression in the ARC of obese rats was greater for c-Jun than for c-Fos. These results suggest a possible difference in Fos immunoreactivity in hypothalamic resistance to circulating satiety factors in genetically obese Zucker rats.
- 社団法人 日本農芸化学会の論文
- 2005-10-23
著者
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KIM Hye
Department of Food and Nutrition, Chungnam National University
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CHUNG Joo-Ho
Departments of Pharmacology, College of Medicine, Kyung Hee University
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Kim Hye-kyung
Dep. Of Food And Biotechnology Hanseo Univ.
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Kim Hye
韓国
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Kim Hye
Department Of Food And Biotechnology Hanseo University
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Lee Bong-hee
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Lee Bong-hee
韓国
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KIM Mi-Ja
Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University
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LIM Beong
Department of Life Science, Konkuk University
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LIM Yoongho
Department of Molecular Biotechnology, BMIC, Konkuk University
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KANG Soon
Department of Molecular Biotechnology, BMIC, Konkuk University
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Yazawa K
九州大学 農学部生物機能化学食糧化学
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Kang Soon
Department Of Biology Gyeongsang National University
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Kim Mi-ja
Department Of Obesity Management Graduate School Of Obesity Science Dongduk Women's University:
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Lim B
Department Of Life Science Konkuk University
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Lim Beong
Department Of Applied Biochemistry Konkuk University
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Lim Beong
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture 46-09 Ky
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Kang Soon
Department Of Molecular Biotechnology Bmic Konkuk University
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Lim Yoongho
Department Of Molecular Biotechnology Bmic Konkuk University
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Chung Joo-ho
韓国
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Chung Joo-ho
Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi
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Lim Beong
Department Of Life Science Konkuk University
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CHANG Un-Jae
Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University
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Chang Un-jae
Department Of Obesity Management Graduate School Of Obesity Science Dongduk Women's University
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Chang Un-jae
Department Of Food And Nutrition Dongduk Women's University
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Yamada K
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Kim Hyun-mi
Department Of Pharmaceutical Lab. Central Research Institute Ilyang Pharm Co.
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Kim Hye
Department Of Anesthesiology And Pain Medicine Konkuk University Chungju-hospital
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Lim Beong
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Kim Mi-ja
Department Of Obesity Management Graduate School Of Obesity Science Dongduk Women's University
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Kang Soon
Department Of Fermented Food Science Seoul University Of Venture & Information
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Kim Hye
Department of Food and Biotechnology, Hanseo University
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KANG Soon
Department of Applied Biology and Chemistry, Konkuk University
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