Inhibitory Effect of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts
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概要
- 論文の詳細を見る
Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.
- 社団法人 日本農芸化学会の論文
- 2005-11-23
著者
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Kim Hye-kyung
Dep. Of Food And Biotechnology Hanseo Univ.
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Kim Hye
韓国
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Jun Woo-jin
Department Of Food And Nutrition Chonnam National University
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Heo Ho-jin
Jeonnam Innovation Agency
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Shin Dong-hoon
韓国
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Shin D‐h
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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Shin Dong‐hoon
Department Of Food And Biotechnology Korea University
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Shin Dong-hoon
Department Of Preventive Medicine School Of Medicine & Institute For Medical Genetics Keimyung U
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Shin Dong-hoon
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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KIM Hye-Kyung
Department of Food Biotechnology, Hanseo University
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Cho Hong
Dep. Of Food And Biotechnology Korea Univ.
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Cho Hong-yon
Dep. Of Food Technol. Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Shin Dong-hoon
Department Of Food And Biotechnology Korea University
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Cho Hong
Graduate School Of Biotechnology Korea University
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Cho Hong-yon
Department Of Food Sience And Biotechnology Graduate School Of Biotechnology Korea University
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Lee Yoo-hyun
韓国
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Hong B‐s
Department Of Food Science And Technology Graduate School Of Biotechnology Korea University
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Kim Hyun-mi
Department Of Pharmaceutical Lab. Central Research Institute Ilyang Pharm Co.
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HO Jin-Nyoung
Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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LEE Yoo-Hyun
Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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LEE Yun-Dong
Division of Food Contaminant, Korea Food and Drug Administration
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HONG Bum-Shik
Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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Lee Yun-dong
Division Of Food Contaminant Korea Food And Drug Administration
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Shin D‐h
Dep. Of Food And Biotechnology Korea Univ.
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Lee Yoo-hyun
Department Of Food And Nutrition University Of Suwon
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Cho Hong-yon
Department Of Food Science And Biotechnology Graduate School Of Biotechnology Korea University
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Hong Bumshik
Department Of Food And Biotechnology Korea University
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Cho Hong-yon
Department Of Food And Biotechnology Korea University
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Kim Hye
Department of Food and Biotechnology, Hanseo University
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SHIN Dong
Department of Food and Biotechnology, Korea University
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HONG Bum-Shik
Department of Food and Biotechnology, Korea University
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KIM Hye-Kyung
Department of Food and Biotechnology, Hanseo University
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