Protective Effects of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Oxidative Stress in Human Skin Fibroblasts(Pharmacognosy)
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概要
- 論文の詳細を見る
Ultraviolet-B (UVB) irradiation has been demonstrated to produce reactive oxygen species (ROS) in the cells and skin, which induces the synthesis of matrix metalloproteinases (MMPs), causing skin photoaging. Using the human skin fibroblast HS68 cell line in the present study, we investigated the photoprotective effects of aucubin from Eucommia ulmoides. Pretreatment with aucubin significantly inhibited the production of MMP-1 by 57% when compared to the UVB-irradiated cells. Additionally, the senescence-associated β-galactosidase (SA β-gal) activity was markedly decreased in the presence of aucubin, which indicates it as an antiphoto-induced aging compound. As the effect of aucubin was determined against ROS, the inhibited ROS formation and malondialdehyde (MDA) levels, and the increased cell viability and glutathione (GSH) level were observed with aucubin under UVB irradiation. Based upon these results, it was suggested that aucubin might play an important role in the cellular defense mechanism against UV radiation-induced photoaging. An understanding of the antioxidant properties of aucubin could, in part, act to elucidate its protective mechanism on the human skin photoaging.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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PARK Jong
Division of Materials and Chemical Engineering, Hanyang University
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Shin Dong
Department of Anatomy, Ajou University School of Medicine
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KIM Hye
Department of Food and Nutrition, Chungnam National University
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Kim Hye-kyung
Dep. Of Food And Biotechnology Hanseo Univ.
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Kim Hye
韓国
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Jun Woo
Dep. Of Food And Nutrition Chonnam Univ.
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Jun W
Graduate School Of Biotechnology Korea University
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Shin Dong
Department Of Agricultural Chemistry The University Of Tokyo
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Shin Dong-hoon
韓国
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Shin D‐h
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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Shin Dong‐hoon
Department Of Food And Biotechnology Korea University
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Park Jong
Division Of Cardiology Asan Medical Center University Of Ulsan College Of Medicine
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CHO Hong
Department of Food and Biotechnology, Korea University
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Cho Hong
Dep. Of Food And Biotechnology Korea Univ.
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Cho Hong-yon
Dep. Of Food Technol. Graduate School Of Life Sciences And Biotechnology Korea Univ.
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HO Jin
Department of Food Technology, Graduated School of Life Sciences and Biotechnology, Korea University
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LEE Yoo
Department of Food Technology, Graduated School of Life Sciences and Biotechnology, Korea University
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JUN Woo
Department of Food and Nutrition, Chonnam National University
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HONG Bum
Department of Food Technology, Graduated School of Life Sciences and Biotechnology, Korea University
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Cho Hong
Graduate School Of Biotechnology Korea University
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Lee Yoo
Department Of Chemical Engineering And Bioprocess Engineering Research Center Korea Advanced Institu
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Lee Yoo
Department Of Food Technology Graduated School Of Life Sciences And Biotechnology Korea University
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Kim Hyun-mi
Department Of Pharmaceutical Lab. Central Research Institute Ilyang Pharm Co.
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Ho Jin
Department Of Food Technology Graduated School Of Life Sciences And Biotechnology Korea University
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Kim Hye
Department Of Anesthesiology And Pain Medicine Konkuk University Chungju-hospital
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Jun Woo
Department Of Food And Nutrition Chonnam University
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Cho Hong
Department Of Food And Biotechnology Korea University
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Park Jong
Division Of Food Microbiology Korea Food And Drug Administration
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Kim Hye
Department of Food and Biotechnology, Hanseo University
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SHIN Dong
Department of Food and Biotechnology, Korea University
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CHO Hong
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine
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