Inhibitory Effect of Poncirus trifoliate on Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment
スポンサーリンク
概要
- 論文の詳細を見る
Various native Korean plants were screened to find an effective acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer’s disease (AD). Among these plants, the ethanol extract of Poncirus trifoliate was selected for isolating the AChE inhibitor because it exhibited the highest inhibitory activity (47.31%). To separate the active compound from Poncirus trifoliate, solvent partition, open column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were utilized. The putative chemical structure of the AChE inhibitor was identified as methoxsalen by successive analysis with electron ionization mass spectrometry (EI-MS) and 13C/1H-nuclear magnetic resonance (NMR). To confirm the attenuating effect of the Poncirus trifoliate extract against trimethyltin (TMT)-induced neurotoxicity, in vivo behavior tests were carried out. Our findings suggest that the Poncirus trifoliate extract significantly reversed TMT-induced learning and memory impairment. These results demonstrate that the Poncirus trifoliate extract could possess a wide range of beneficial activities for neurodegenerative disorders, notably AD.
- 社団法人 日本農芸化学会の論文
- 2009-05-23
著者
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KIM Hye
Department of Food and Nutrition, Chungnam National University
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Kim Jae
Department of Anatomy, College of Medicine, Pusan National University
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Kim Hye-kyung
Dep. Of Food And Biotechnology Hanseo Univ.
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Kim Hye
韓国
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Kim Young
Dep. Of Food And Biotechnology Korea Univ.
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KIM Eun
Department of Phpysics, Hanyang University
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Choi Soo
Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Shin Dong-hoon
韓国
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Shin D‐h
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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Shin Dong‐hoon
Department Of Food And Biotechnology Korea University
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Shin Dong-hoon
Department Of Preventive Medicine School Of Medicine & Institute For Medical Genetics Keimyung U
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Bae Heyri
Department of Food and Biotechnology, Korea University
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Kim Mi-Jeong
Brain Korea 21 Project for Medicine, Yonsei University
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CHO Hong
Department of Food and Biotechnology, Korea University
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HWANG Han-Joon
Department of Food and Biotechnology, Korea University
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LIM Seung
Brain Korea 21 Project for Medicine, Yonsei University
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KIM Bok
Han-il Ginseng Industry Company
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KIM Eunki
Department of Biological Engineering, Inha University
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Lim Seung
Brain Korea 21 Project For Medicine Yonsei Univ.
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Kim Mi
Department Of Food And Biotechnology Korea University
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Cho Hong
Dep. Of Food And Biotechnology Korea Univ.
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Cho Hong-yon
Dep. Of Food Technol. Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Shin Dong-hoon
Department Of Food And Biotechnology Korea University
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Kim Eun-ki
Dep. Of Biological Engineering Inha Univ.
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Cho Hong
Graduate School Of Biotechnology Korea University
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Kim Hyun-mi
Department Of Pharmaceutical Lab. Central Research Institute Ilyang Pharm Co.
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Kim Jae
Department Of Anatomy College Of Medicine Pusan National University
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Kim Hye
Department Of Anesthesiology And Pain Medicine Konkuk University Chungju-hospital
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Lim Seung-taik
Graduate School Of Life Sciences And Biotechnology Korea University
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Lim Seung-taik
Department Of Food Technology School Of Life Sciences And Biotechnology Korea University
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Hwang Han-joon
Department Of Food And Biotechnology Korea University
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Kim Mi-jeong
Brain Korea 21 Project For Medicine Yonsei University
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Cho Hong
Department Of Food And Biotechnology Korea University
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Kim Eun
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Bae Heyri
Department Of Food And Biotechnology Korea University
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Kim Jae
Department Of Food And Biotechnology Korea University
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Kim Jae
Department Of Anatomy And Brain Korea 21 Project For Medical Science Yonsei University College Of Medicine
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Kim Hye
Department of Food and Biotechnology, Hanseo University
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Kim Mi-Jeong
Department of Food and Biotechnology, Korea University
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SHIN Dong
Department of Food and Biotechnology, Korea University
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CHO Hong
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine
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Kim Jae
Deparment of Obstetrics and Gynecology, Seoul National University Collge of Medicine
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KIM Eun
Department of Agricultural Biotechnology, Seoul National University
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