The Suppressive Effect of β-Glucan on the Production of Tumor Necrosis Factor-Alpha in BV2 Microglial Cells

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概要

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• β-Glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of β-glucan on the production of tumor necrosis factor-alpha (TNF-α), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. β-Glucan decreased the production and expression of TNF-α. In addition, it blocked LPS-stimulated activation of nuclear factor kappa B (NF-κB). Hence β-glucan might suppress LPS-stimulated TNF-α production by inhibiting NF-κB in BV2 microglial cells.

著者

• KIM Hye

  Department of Food and Nutrition, Chungnam National University

• CHUNG Joo-Ho

  Departments of Pharmacology, College of Medicine, Kyung Hee University

• YIM Sung-Vin

  Department of Pharmacology, College of Medicine, Kangwon National University

• KIM Young

  National Nanofab Center

• KIM Mi-Ja

  Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University

• KANG Soon

  Department of Molecular Biotechnology, BMIC, Konkuk University

• JUNG Kyung

  Department of Pharmacology, College of Medicine, Kyung Hee University

• HA Eunyoung

  Department of Biochemistry, College of Medicine, Kyung Hee University

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