Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress

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概要

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• Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-β1)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.

• 社団法人 日本農芸化学会の論文

著者

• LEE Chongmu

  Department of Materials Science and Engineering, Inha University

• JUNG Kyung

  Department of Pharmacology, College of Medicine, Kyung Hee University

• HONG Sang-Won

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• LEE Hee-Seung

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• ZHENG Hong-Mei

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• CHOI Myung-Joo

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• HONG Soon-Sun

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

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