Betaine Modulates Age-Related NF-κB by Thiol-Enhancing Action(Biochemistry)
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概要
- 論文の詳細を見る
Depletion of glutathione levels and perturbations in redox status are considered to play a crucial role in aging and chronic inflammatory processes through the activation of redox sensitive transcription factors, including nuclear factor-κB (NF-κB). In the current study, we assessed the regulatory action of dietary betaine in the suppression of NF-κB by comparing kidney tissue from old, betaine-supplemented rats or non-betaine-supplemented rats (age 21 months) and 7 month-old rats. In addition, cultured HEK 293T cells were utilized for the molecular assessment of betaine's restorative ability of redox status when treating cells with potent glutathione (GSH)-depleting agents. Results showed that in old rats a short-term feeding (10d) with betaine attenuated the age-related decrease in thiol levels, increase in reactive species and TNFα expression via NF-κB activation, compared to the young controls. These findings were verified in the cell-cultured system. Further investigations found that redox imbalance due to thiol depletion caused increased NF-κB activation, and cyclooxygenase (COX)-2 and TNFα levels, both of which were suppressed by betaine treatment. Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFα via NF-κB activation during aging.
- 公益社団法人日本薬学会の論文
- 2007-12-01
著者
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KIM Ji
Department of Polymer Science and Engineering, Kumoh National Institute of Technology
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JUNG Kyung
Department of Pharmacology, College of Medicine, Kyung Hee University
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Jung Kyung
Department Of Chemistry Advanced Materials Chemistry Research Center Korea University
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Jung Kyung
Department Of Pharmacy College Of Pharmacy
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Kim Ji
Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center
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CHUNG Hae
Department of Pharmacy, Pusan National University
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Kim Ji
Department Of Pharmacy College Of Pharmacy
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Yu Byung
Longevity Life Science And Technology Institutes Pusan National University:department Of Physiology
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Chung Hae
Department Of Pharmacy College Of Pharmacy:longevity Life Science And Technology Institutes Pusan Na
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GO Eun
Department of Pharmacy, College of Pharmacy
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LIM Hyunae
Department of Pharmacy, College of Pharmacy
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LIM Hyeang
Department of Pharmacy, College of Pharmacy
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Go Eun
Department Of Pharmacy College Of Pharmacy
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Lim Hyunae
Department Of Pharmacy College Of Pharmacy
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Jung Kyung
Department Of Biomedical Sciences And Nceed School Of Medicine Inha University
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Chung Hae
Department Of Pediatrics Chonnam National University Medical School
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Chung Hae
Department Of Kinesiology And Community Health University Of Illinois
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Kim Ji
Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea
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