Inhibitory Effect of the Saponins Derived from Roots of Platycodon grandiflorum on Carrageenan-Induced Inflammation

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概要

• 論文の詳細を見る

• Previous studies have reported that the saponins isolated from the roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil saponins (CKS), inhibited cyclooxygenase-2 (COX-2) expression in cultured lipopolysaccharide-activated macrophages. The aim of this presented study was to confirm the anti-inflammatory effects of CKS by examining their effect on the inflammatory response induced by carrageenan in a rat by using an acute air pouch inflammation model. CKS significantly reduced the levels of the inflammatory process markers in the air pouch, such as the volume of exudates, the amount of protein and the number of leukocytes and neutrophils. The levels of TNF-α and prostaglandin E2 (PGE2) were also markedly lower in the air pouch of the CKS-treated animals than in the controls. An immunoblot analysis showed that CKS reduced the COX-2 expression level in the exudate cells. In addition, CKS significantly reduced the paw edema induced by carrageenan and also markedly reduced the level of PGE2 production in the inflamed paw. These results suggest that CKS had significant anti-inflammatory effects in vivo.

• 社団法人 日本農芸化学会の論文
• 2006-04-23

著者

• KIM Dong

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• KIM Ji

  Department of Polymer Science and Engineering, Kumoh National Institute of Technology

• Hwang Yong

  Department Of Pediatrics Seoul National University College Of Medicine

• Kim Ji

  Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center

• Kim Ji

  Department Of Pharmacy College Of Pharmacy Research Center For Proteineous Materials Chosun Universi

• Kim Dong

  Department Of Pathology College Of Oriental Medicine Daejeon University

• Roh Seong

  Jangsaeng Doraji Research Institute Of Biotechnology Jangsaeng Doraji Co. Ltd.

• HAN Eun

  Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun Unive

• CHUNG Young

  Division of Food Science, Chinju International University

• JEONG Hye

  Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun Unive

• Hwang Yong

  Department Of Pharmacy College Of Pharmacy Research Center For Proteineous Materials Chosun Universi

• Han Eun

  Department Of Pharmacy College Of Pharmacy Research Center For Proteineous Materials Chosun Universi

• Han Eun

  Department Of Life Science College Of Natural Sciences Hanyang University

• Jeong Hye

  Department Of Electrical Engineering Yeungnam University

• Jeong Hye

  Coll. Of Pharmacy Chungnam National Univ.

• Jeong Hye

  Department Of Pharmacy College Of Pharmacy Research Center For Proteineous Materials Chosun Universi

• Hwang Yong

  Department Of Neurosurgery Epilepsy Center Inje University College Of Medicine Sanggye Paik Hospital

• Kim Dong

  Department Of Anatomy School Of Medicine Kyungpook National University

• Chung Young

  Division Of Food Science Chinju International University

• Kim Ji

  Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea

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