Histological Study on the Effect of Electrolyzed Reduced Water-Bathing on UVB Radiation-Induced Skin Injury in Hairless Mice

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概要

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• Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mechanism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice were irradiated with UVB to cause skin injury, followed by individually taken a bath in ERW (ERW-bathing) and tap water (TW-bathing) for 21 d. We examined cytokines profile in acute period, and histological and ultrastructural observation of skin in chronic period. We found that UVB-mediated skin injury of ERW-bathing group was significantly low compared to TW control group in the early stage of experiment. Consistently, epidermal thickening as well as the number of dermal mast cell was significantly lowered in ERW-bathing group. Defection of corneocytes under the scanning electron microscope was less observed in ERW-bathing group than in TW-bathing group. Further, the level of interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-12p70 in ERW group decreased whereas those of IL-10 increased. Collectively, our data indicate that ERW-bathing significantly reduces UVB-induced skin damage through influencing pro-/anti-inflammatory cytokine balance in hairless mice. This suggests that ERW-bathing has a positive effect on acute UVB-mediated skin disorders. This is the first report on bathing effects of ERW in UVB-induced skin injury.

• 公益社団法人　日本薬学会の論文

著者

• LEE Kyu

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• KIM Dong

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• Lee Kyu

  Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University

• Chang Byung

  Department Of Cosmetology Hanseo University

• Kim Dong

  Department Of Anatomy School Of Medicine Kyungpook National University

• Yoon Kyung

  Department of Information Engineering, Korea University

• Huang Xue

  Department of Anesthesiology, Yanbian University Hospital, Yanbian University

• Yoon Yang

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• Kim Soo-Ki

  Department of Microbiology, Wonju College of Medicine, Yonsei University

• Song Soon

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• Yoon Kyung

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• KIM Soo-Ki

  Department of Animal Science and Environment, Konkuk University

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