Inhibitory Effects of 4-n-Butylresorcinol on Tyrosinase Activity and Melanin Synthesis(Pharmacology)

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概要

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• In this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase.

• 社団法人日本薬学会の論文
• 2005-12-01

著者

• KIM Dong

  Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University

• Park Kyoung

  Department of Laboratory Medicine, Seoul National University College of Medicine

• Kim Dong-seok

  韓国

• Park K

  Department Of Dermatology Seoul National University College Of Medicine And Department Of Dermatolog

• PARK Seo

  Department of Obstetrics and Gynecology, Maria Infatility Hospital

• Kim Myo-kyoung

  米国

• Kim Myo-kyoung

  Pharmacy Practice Thomas J. Long School Of Pharmacy University Of The Pacific

• Kim So-young

  韓国

• Kim So

  Department Of Neuroscience College Of Medicine Ewha Womans University

• Kim So

  Department Of Dermatology Seoul National University College Of Medicine

• Youn Sang

  韓国

• KWON Sun

  Department of Dermatology and Artificial Organ Laboratory of the Clinical Research Institute, Seoul

• YOUN Sang

  Department of Dermatology, Seoul National University Hospital

• Youn Sang

  Department Of Dermatology Seoul National University College Of Medicine

• NA Jung

  Department of Dermatology, Seoul National University College of Medicine, and Department of Dermatol

• CHOI Yeong

  Department of Dermatology, Seoul National University College of Medicine

• KIM Myo

  Pharmacy Practice, Thomas J. Long School of Pharmacy, University of the Pacific

• Kim Dong

  Department Of Dermatology Seoul National University College Of Medicine:research Division For Human

• Kim So

  Department Of Cardiology College Of Medicine Catholic University Of Daegu

• Park Kyoung

  Department Of Dermatology Clinical Research Institute Seoul National University Hospital College Of

• Kim Myo

  Pharmacy Practice Thomas J. Long School Of Pharmacy University Of The Pacific

• Park Seo

  Department Of Dermatology Seoul National University College Of Medicine

• Park Kyoung-chan

  Department Of Dermatology Seoul National University College Of Medicine And Seoul National Universit

• Na Jung

  Department Of Dermatology Seoul National University College Of Medicine And Department Of Dermatolog

• Kwon Sun

  Department Of Dermatology Seoul National University College Of Medicine

• Park Kyoung

  Department Of Dermatology Seoul National University College Of Medicine Clinical Research Institute

• Choi Yeong

  Department Of Dermatology Seoul National University College Of Medicine

• Kim Dong

  Department Of Anatomy School Of Medicine Kyungpook National University

• Park Kyoung-chan

  Departments Of Dermatology Seoul National University College Of Medicine

• Park Seo-hyoung

  Department Of Dermatology Seoul National University College Of Medicine

• Youn Sang

  Department Of Dermatology College Of Medicine Seoul National University

• Kim Dong

  Department Of Dermatology And Artificial Organ Laboratory Clinical Research Institute Seoul National

• Kim Dong-seok

  Department Of Dermatology Seoul National University Bundang Hospital

• Kim So-young

  Department Of Biochemistry And Molecular Biology Cancer Research Center Seoul National University Co

• Park Kyoung

  Department Of Dermatology Seoul National University College Of Medicine Seoul National University Ho

• Kim Dong-seok

  Department Of Biochemistry Chung-ang University College Of Medicine

• PARK Kyoung

  Department of Biology, SungShin Women's University

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