Effects of endogenous and exogenous nitric oxide on electrical responses of circular smooth muscle isolated from the guinea-pig stomach antrum
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概要
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The effects of endogenous and exogenous nitric oxide (NO) on electrical activity were investigated in circular smooth muscle preparations isolated from the guinea-pig stomach antrum. The actions of endogenous NO were evaluated from the effects of inhibition of NO synthesis by N^ω-nitro-L-arginine (nitroarginine), while those of exogenous NO were assessed from the effects of SIN-1, an NO donor. Antral circular smooth muscle generated slow potentials periodically at a frequency of about 1 cycle per min (cpm), and unitary potentials were also generated in a random fashion in the interval between slow potentials. Application of nitroarginine (10^<-5> M) increased the frequency of slow potentials, with no significant alteration of the resting membrane potential and amplitude of slow potentials. Frequency analysis of unitary potentials revealed that nitroarginine also increased the spectral density at 0.01-1 Hz frequency. The refractory period for the generation of slow potentials evoked by depolarizing pulses was about 10 s, but was decreased to 6 s by nitroarginine. In the presence of nitroarginine, SIN-1 (10^<-9>- 10^<-7> M) reduced the amplitude and frequency of slow potentials: low concentrations (< 10^<-8> M) reduced only the frequency of slow potentials, while higher concentrations (10^<-8>- 10^<-7> M) reduced both the amplitude and frequency of slow potentials, in a concentration-dependent manner, before abolishing the slow potentials. The power spectrum of the unitary potentials indicated that SIN-1 (>10^<-8> M) reduced the spectral density at 0.01-1 Hz frequency. The refractory period for the generation of slow potentials was increased again to about 10 s by SIN-1. Thus, the excitatory effects of nitroarginine could be antagonized by SIN-1, suggesting that the inhibitory effects of endogenous NO are comparable to those of exogenous NO produced by SIN-1. The results also suggested that the effects of NO on smooth muscle are insignificant and NO selectively inhibits the activity of intramuscular interstitial cells of Cajal (ICC-IM).
- 日本平滑筋学会の論文
著者
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LEE Kyu
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
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Kim Ki
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res
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So Insuk
Department of Physiology, Seoul National University College of Medicine
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SUZUKI Hikaru
Department of Physiology, Nagoya City University Medical School
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NAKAMURA Eri
Department of Physiology, Nagoya City University Medical School
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So Insuk
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Lee Kyu
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Lee Kyu
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Suzuki Hikaru
Department Of Physiology Nagoya City University Medical School
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Suzuki Hikaru
Department Of Cell Physiology Nagoya City University Medical School
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Nakamura Eri
Department Of Cell Physiology Nagoya City University Medical School
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Nakamura Eri
Department Of Physiology Nagoya City University Medical School
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Suzuki Hikaru
Department Of Cardiology Tokyo Women's Medical University
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Kim Ki
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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