Effects of Arachidonic Acid on ATP-Sensitive K^+ Current in Murine Colonic Smooth Muscle Cells
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概要
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The effects of arachidonic acid (AA) and the mechanism through which it modulates ATP-sensitive K+ (KATP) currents were examined in single smooth muscle cells of murine proximal colon. In the current-clamping mode, AA and glibenclamide induced depolarization of membrane potential. Using 0.1 mM ATP and 140 mM K+ solution in the pipette and 90 mM K+ in the bath solution at a −80 mV of holding potential, pinacidil activated the glibenclamide-sensitive inward current. The potential of these currents was reversed to near the equilibrium potential of K+ by 60 mM K+ in the bath solution. AA inhibited KATP currents in a dose-dependent manner. This inhibition was not changed when 1 mM GDPβS was present in the pipette. Chelerythrine, protein kinase C inhibitor, did not block the AA effects. Superoxide dismutase and metabolic inhibitors (indomethacin and nordihydroguaiacretic acid) of AA did not affect the AA-induced inhibition. Eicosatetraynoic acid, a nonmetabolizable analogue of AA, inhibited the KATP currents. These results suggest that AA-induced inhibition of KATP currents is not mediated by G-protein or protein kinase C activation. The inhibitory action is likely to be a possible mechanism of AA-induced membrane depolarization.
- 社団法人 日本薬理学会の論文
- 2002-09-01
著者
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Kim Ki
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res
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So Insuk
Department of Physiology, Seoul National University College of Medicine
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Kim Ki
韓国
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Kim K
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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So Insuk
Department Of Physiology Seoul National University College Of Medicine
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So Insuk
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Jun Jae
Department of Physiology, Chosun University College of Medicine
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Kim Ki
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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Jun Jae
Department Of Physiology College Of Medicine Chosun University
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YOU Ho
Department of Pharmacology, College of Medicine, Chosun University
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SIM Jae
Department of Physiology and Biophysics, Seoul National University College of Medicine
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JANG In
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine
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You Ho
Department Of Pharmacology College Of Medicine Chosun University
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YEUM Cheol
Department of Physiology, College of Medicine, Chosun University
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PARK Yoo
Department of Internal Medicine College of Medicine, Chosun University
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KONG In
Department of Physiology, Wonju College of Medicine, Yonsei University
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Sim Jae
Department Of Physiology And Biophysics College Of Medicine Seoul National University
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Jun Jae
Department Of Internal Medicine Kyungpook National University Hospital
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Kong In
Department Of Physiology Wonju College Of Medicine Yonsei University
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Kong In
Department Of Physiology And Institute Of Lifelong Health Yonsei University Wonju College Of Medicin
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Jang In
Department Of Anatomy College Of Medicine Chosun University
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Park Yoo
Department Of Internal Medicine College Of Medicine Chosun University
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Park Yoo
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Yeum Cheol
Department Of Physiology College Of Medicine Chosun University
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Sim Jae
Department Of Materials Engineering Sungkyunkwan University
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