Incremental Prognostic Value of C-Reactive Protein and N-Terminal ProB-Type Natriuretic Peptide in Acute Coronary Syndrome
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概要
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Background Cardiac biomarkers, including high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-Btype natriuretic peptide (NT-proBNP) and cardiac troponin-I (Tn-I), have been associated with an adverse outcome in patients with acute coronary syndrome (ACS). Thus, in the present study the incremental prognostic value of these cardiac biomarkers was evaluated for risk stratification of ACS. Methods and Results The baseline levels of hs-CRP, NT-proBNP and Tn-I were measured in 215 patients (140 males; 65±46 years) with ACS: ST-elevation myocardial infarction (STEMI): 56; non-ST-elevation myocardial infarction (NSTEMI): 98; unstable angina (UA): 61. The patients were retrospectively followed up for a mean of 246 days. There were 24 cardiac events: STEMI: 1, NSTEMI: 6, UA: 6, chronic heart failure: 1, death: 10. The baseline levels of hs-CRP and NT-proBNP were significantly higher in the patients with cardiac events than in those without events. After adjustment for major clinical prognostic factors, hs-CRP and NT-proBNP remained significantly independent predictors for cardiac events. Patients with hs-CRP level >3.5mg/L and NT-proBNP level >500pg/ml had an 11-fold higher risk for cardiac events than those with hs-CRP level ≤3.5mg/L and NT-proBNP level ≤500pg/ml. Conclusion The combination of both cardiac markers has an incremental value in the risk stratification of patients with ACS.
- 2006-10-20
著者
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Lee Jang
Kyungpook National University Hospital
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Chae Shung-chull
Kyungpook National University Hospital
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Jun Jae-eun
Kyungpook National University Hospital
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Park Hun
Department Of Biomedical Engineering School Of Medicine Kyung Hee University
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YANG Dong
Department of Obstetrics & Gynecology, Second Affiliated Hospital of Sun Yat-Sen University
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Kim Hyung
Division Of Cardiology Department Of Internal Medicine Kyungpook National University
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Kim Hyungseop
(Current status) Keimyung University Dongsan Medical Center
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Park Yongwhi
Department of Internal Medicine, Kyungpook National University Hospital
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Han Juyup
Department of Internal Medicine, Kyungpook National University Hospital
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Lee Hyunsang
Department of Internal Medicine, Kyungpook National University Hospital
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Kang Hyunjae
Department of Internal Medicine, Kyungpook National University Hospital
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Cho Yongkeun
Department of Internal Medicine, Kyungpook National University Hospital
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Chae Shung
Department of Internal Medicine, Kyungpook National University Hospital
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Jun Jae-Eun
Department of Internal Medicine, Kyungpook National University Hospital
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Park Wee-Hyun
Department of Internal Medicine, Kyungpook National University Hospital
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Park Yonghwi
Division of Cardiology, Department of Internal Medicine, Kyungpook National University
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Lee Hyunsang
Division of Cardiology, Department of Internal Medicine, Kyungpook National University
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Kang Hyunjae
Division of Cardiology, Department of Internal Medicine, Kyungpook National University
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Kim Hyungseop
Kyungpook National University Hospital
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Yang Dong
Kyungpook National University Hospital
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Park Wee-Hyun
Kyungpook National University Hospital
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Heo Jungho
Kosin University Gospel Hospital
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Kang Hyunjae
Division Of Cardiology Department Of Internal Medicine Kyungpook National University
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Park Yonghwi
Division Of Cardiology Department Of Internal Medicine Kyungpook National University
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Lee Hyunsang
Division Of Cardiology Department Of Internal Medicine Kyungpook National University
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Yang Dong
Department Of Computer Science Tokyo Institute Of Techonology
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Jun Jae
Department Of Internal Medicine Kyungpook National University Hospital
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Park Hun-sik
Kyungpook National University Hospital
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Park Wee
Department Of Internal Medicine Kyungpook National University Hospital
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Chae Shung
Department Of Internal Medicine Kyungpook National University Hospital
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Park Hun
Department Of Internal Medicine Kyungpook National University Hospital
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Cho Yongkeun
Department Of Internal Medicine Kyungpook National University Hospital
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Yang Dong
Department Of Internal Medicine Kyungpook National University Hospital
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Han Juyup
Department Of Internal Medicine Kyungpook National University Hospital
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Lee Jang
Department Of Internal Medicine Kyungpook National University Hospital
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Jun Jae-eun
Department Of Internal Medicine Kyungpook National University Hospital
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