Effects of Ginseng Total Saponins on Pacemaker Currents of Interstitial Cells of Cajal from the Small Intestine of Mice(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• Although ginsenosides have a variety of physiologic or pharmacologic functions in various regions, there are only a few reports on the effects of ginsenosides on gastrointestinal (GI) motility. We studied the modulation of pacemaker activities by ginseng total saponins in the interstitial cells of Cajal (ICC) using the whole cell patch-clamp technique. Externally applied ginseng total saponins (GTS) produced membrane depolarization in the current-clamp mode and increased tonic inward pacemaker currents in the voltage-clamp mode. The application of flufenamic acid or niflumic acid abolished the generation of pacemaker currents, but only treatment with flufenamic acid inhibited the GTS-induced tonic inward currents. The tonic inward currents induced by GTS were not inhibited by the intracellular application of guanosine 5'-[β-thio]diphosphate trilithium salt. Pretreatment with a Ca^<2+>-free solution, with U-73122, an active phospholipase C inhibitor, and with thapsigargin, a Ca^<2'>-ATPase inhibitor of the endoplasmic reticulum, abolished the generation of pacemaker currents and suppressed the GTS-induced action. However, treatment with chelerythrine and calphostin C, protein kinase C inhibitors, did not block the GTS-induced effects on the pacemaker currents. These results suggest that ginsenosides modulate the pacemaker activities of the ICC, and the ICC can be targets for ginsenosides, and their interaction can affect intestinal motility.

• 公益社団法人日本薬学会の論文
• 2007-11-01

著者

• PARK Jong

  Department of Internal Medicine, Chonnam National University Hospital

• Kim Ki

  Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res

• So Insuk

  Department of Physiology, Seoul National University College of Medicine

• Kim Ki

  韓国

• Kim K

  Department Of Physiology School Of Medicine Gachon University Of Medicine And Science

• So Insuk

  Department Of Physiology Seoul National University College Of Medicine

• So Insuk

  Department Of Physiology And Biophysics Seoul National University College Of Medicine

• Choi Seok

  Department of Physiology, Chosun University College of Medicine

• Jun Jae

  Department of Physiology, Chosun University College of Medicine

• JEONG Han

  Department of Chemistry, University of Ulsan

• Kim Ki

  Department Of Physiology School Of Medicine Gachon University Of Medicine And Science

• Jun Jae

  Department Of Physiology College Of Medicine Chosun University

• Parajuli Shankar

  Department Of Physiology College Of Medicine Chosun University

• Kim Hyun

  Division Of Gastroenterology Department Of Internal Medicine Wonju Christian Hospital Yonsei Univers

• Kim Hyun

  Division Of Gastroenterology Department Of Internal Medicine Chonnam National University Medical Sch

• YEUM Cheol

  Department of Physiology, College of Medicine, Chosun University

• Jun Jae

  Department Of Internal Medicine Kyungpook National University Hospital

• Jeong Han

  Department Of Physiology Chonnam National University Medical School

• Yeum Cheol

  Department Of Physiology College Of Medicine Chosun University

• Kim Ki

  Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University

• Kim Hyun

  Division Of Ceramics Korea Institute Of Science And Technology

• Park Jong

  Department Of Physiology Chonnam National University Medical School

• Park Jong

  Department Mathematics Pusan National University

• Jeong Han

  Department Of Chemistry University Of Ulsan

• Choi Seok

  Department Of Physiology College Of Medicine Chosun University

• Choi Seok

  Department Of Information And Communications Kwangju Institute Of Science And Technology

• Jeong Han

  Department Of Cardiology Cardiovascular Center Korea University Anam Hospital

関連論文

• Long-Term Clinical Course of Patients With Isolated Myocardial Bridge
• Different channel modulation in arterial smooth muscle cells of diabetes(Special lecture, 52^ Annual Meeting of the Japan Society of Smooth Muscle Research)
• Pairing-Friendly Elliptic Curves with Various Discriminants
• IS-59 The study of tissue mineral concentration in pregnant women who lived in Incheon and outcome of pregnancy(Group8 Perinatology1,International Session)
• Effects of Imatinib Mesylate in Interstitial Cells of Cajal from Murine Small Intestine
• Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage
• Red Ginseng Saponin Extract Attenuates Murine Collagen-Induced Arthritis by Reducing Pro-inflammatory Responses and Matrix Metalloproteinase-3 Expression
• Silk Amino Acids Improve Physical Stamina and Male Reproductive Function of Mice
• Comparison of Metabolic Substrates between Exercise and Cold Exposure in Skaters
• Effect of Cold Acclimation on Antioxidant Status in Cold Acclimated Skaters
• A Case of AV Reentrant Tachycardia due to a Concealed Accessory Pathway with Retrograde Conduction Manifested by Isoproterenol
• IS-46 Inhibitory effect of Nitric oxide on the Proliferation of Endometrial cells
• C_4F_8O/O_2/N-based Additive Gases for Silicon Nitride Plasma Enhanced Chemical Vapor Deposition Chamber Cleaning with Low Global Warming Potentials
• The Interfacial and Diffusion Properties of Copper on Polymide Deposited by Ionized Cluster Beam
• Early Statin Therapy Within 48 Hours Decreased One-Year Major Adverse Cardiac Events in Patients With Acute Myocardial Infarction
• Cubic-Structured HfLaO for the Blocking Layer of a Charge-Trap Type Flash Memory Device
• Hemifacial Seizure of Cerebellar Ganglioglioma Origin: Seizure Control by Tumor Resection
• N-Terminal Pro-B-Type Natriuretic Peptide Predicts Significant Coronary Artery Lesion in the Unstable Angina Patients With Normal Electrocardiogram, Echocardiogram, and Cardiac Enzymes
• Radical Scavenging Activity and Inhibition of Advanced Glycation End Products(AGEs) Formation of Lespedeza Cuneata(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
• Merosin-deficient congenital muscular dystrophy in Korea
• IS-95 Sexual behavior of Korean young women : preliminary study for the introducing of HPV prophylactic vaccine(Group12 Oncology4,International Session)
• Protective activity from hydrophilic and lipophilic free radical generators of Wen-Pi-Tang and its crude drug extracts in LLC-PK_1 cells
• Usefulness of Physical Maneuvers for Prevention of Vasovagal Syncope
• Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats(Pharmacology)
• GM-CSF inhibits apoptosis of neural cells via regulating the expression of apoptosis-related proteins
• IS-100 Prospective study of Epidemiologic factors in HPV infections and Cervical Intraepithelial Neoplasia in Korean women(Group12 Oncology4,International Session)
• Detection of recurrent cervical intraepithelial neoplasia by HPV test after LEEP conization(Oncology 8)
• Rapamycin Down-Regulates Inducible Nitric Oxide Synthase by Inducing Proteasomal Degradation
• Randomized Comparison of Cilostazol vs Clopidogrel After Drug-Eluting Stenting in Diabetic Patients : CIilostazol for Diabetic Patients in Drug-Eluting Stent (CIDES) Trial
• Background Nonselective Cationic Current and the Resting Membrane Potential in Rabbit Aorta Endothelial Cells
• Relationship Between Global Cytosolic Ca^ Concentration and Ca^ activated K^+ Current in Rabbit Cerebral Arterial Myocyte
• Alteration of antioxidant enzymes at the mRNA level during short-term starvation of rockbream Oplegnathus fasciatus
• Prevention of urethral stricture in insertion of an inflatable penile prosthesis
• Immuno-staining with a novel Human Papapillomavirus 16 E7 antibody in various HPV 16 positive tissues(Oncology 7)
• Inhibition of Acyl-CoA:Cholesterol Acyltransferase by Isohalobacillin, a Complex of Novel Cyclic Acylpeptides Produced by Bacillus sp.A1238
• Inhibition of the Binding of Oxidized Low Density Lipoprotein to the Macrophages by Iturin C-related Compounds
• Comparative Middle Term Results of Arthroscopic ACL Reconstruction : A Comparison of Quadrupled Semitendinosus and BPB Tendon
• Dental Anomalies Associated with Axenfeld-Rieger Syndrome
• Analysis of Hu-Huang-Fan Practical Hierarchical Identity-Based Encryption Scheme
• Secondary leukemia in a child conceived using in vitro fertilization
• Effects of endogenous and exogenous nitric oxide on electrical responses of circular smooth muscle isolated from the guinea-pig stomach antrum
• Effects of Ginseng Total Saponins on Pacemaker Currents of Interstitial Cells of Cajal from the Small Intestine of Mice(Pharmacology)
• Effects of Arachidonic Acid on ATP-Sensitive K^+ Current in Murine Colonic Smooth Muscle Cells
• The Properties of Carbachol-Activated Nonselective Cation Channels at the Single Channel Level in Guinea Pig Gastric Myocytes
• Muscarinic Receptors Controlling the Carbachol-Activated Nonselective Cationic Current in Guinea Pig Gastric Smooth Muscle Cells
• Influence of Extracellular Na^+ Removal on Cytosolic Ca^ Concentration in Smooth Muscle Cells of Rabbit Cerebral Artery
• Dual roles of phorbol 12, 13-dibutyrate in the regulation of guinea-pig gastric contraction
• Melastatin-Type transient receptor potential channel 7 is required for intestinal pacemaking activity(Kuriyama Hirosi Award,Program and Abstracts of Papers for 48th Annual Meeting of The Japan Society of Smooth Muscle Research)
• The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract
• Unidirectional Single-Mode 532-nm Nd : YAG Laser Using Intracavity Frequency Doubling in Nonplanar Ring Geometry
• Characteristics of a Birefringence Compensation Scheme in Nd^:YAG Rods Using a Polarization Rotator and Imaging Optics
• Nonselective Cation Channels Activated by the Stimulation of Muscarinic Receptors in Mammalian Gastric Smooth Muscle
• Tsutsugamushi Myocarditis With Congestive Heart Failure and Persistent Atrial Standstill
• Surgical Outcome of Epilepsy Caused by Cortical Dysplasia
• Triplet pregnancy with partial hydatidiform mole coexisting with two fetuses : A case report
• Total peroxyl radical-trapping ability and anti-oxidant vitamins of the umbilical venous plasma and the placenta in pre-eclampsia
• First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma : A retrospective analysis of clinical predictors
• Effect of Anti-Oxidant (Carvedilol and Probucol) Loaded Stents in a Porcine Coronary Restenosis Model
• Pathological characteristics of olive flounder Paralichthys olivaceus experimentally infected with Streptococcus parauberis
• Evolutionary Genetics of the Drosophila montium Subgroup. II. Mitochondrial DNA Variation
• Applications of Permalloy magnetic nanorods array in RF noise suppressor
• Investigation of Polyimide Thin Films Deposited by Ionized Cluster Beam
• Predicting Diametral Creep of the Pressure Tubes in CANDU Reactors Using Fuzzy Neural Networks
• Epidermoid cyst appearing as a malignancy-mimicking subcutaneous lesion on ultrasonography
• Small antennas for ultra-wideband capsule endoscope systems (アンテナ・伝播)
• Effect of Methanol Extract of Zanthoxylum piperitum Leaves and of Its Compound, Protocatechuic Acid, on Hepatic Drug Metabolizing Enzymes and Lipid Peroxidation in Rats(Food & Nutrition Science)
• The Extraction of Vehicle License Plate Region Using Edge Directional Properties of Wavelet Subband
• ON ENERGY DECAY ESTIMATES FOR THE WAVE EQUATION OF KIRCHHOFF TYPE (Nonlinear Analysis and Convex Analysis)
• Direct Effects of Riluzole on 5-Hydroxytryptamine (5-HT)_3 Receptor-Activated Ion Currents in NCB-20 Neuroblastoma Cells
• IS-113 Relationship between hormone receptor status and pathologic factors in patients with endometrial cancer(Group13 Oncology5,International Session)
• Biochemical and genetic analysis of Leigh syndrome patients in Korea
• Mixture of fuels approach for the solution combustion synthesis of LaAlO_3 nanopowders
• NULL CONTROLLABILLITY OF THE INTEGRODIFFERENTIAL EQUATIONS IN BANACH SPACE(Nonlinear Analysis and Convex Analysis)
• A Finite Element Analysis for Near-net-shape Forming of Aluminum Alloy Powder Under Warm Pressing
• Effect of Carbon Source on the Mycelial Growth and Exo-Biopolymer Production by Submerged Culture of Paecilomyces japonica
• Factors Related to the Prevalence of Respiratory Symptoms in Workers in a Petrochemical Complex
• Incidental detection of needle broken in transurethral needle ablation of prostate during transurethral resection of prostate
• Substrate Temperature Dependence of ZnO Films Prepared by Ultrasonic Spray Pyrolysis
• Multidetector Row Computed Tomography Noninvasively Assesses Coronary Reperfusion After Thrombolytic Therapy in Patients With ST Elevation Myocardial Infarction
• Thermoelectric properties of highly oriented Ca_Bi_Co_4O_9 fabricated by rolling process
• IS-87 The inhibitory effect of green tea polyphenol epigallocatechin gallate (EGCG) and curcumin on the inflammation of endometriosis(Group10 Reproduction4,International Session)
• IS-84 Curcumin attenuates the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and cytokines in TNF-α-stimulated human endometriotic stromal cells(Group10 Reproduction4,International Session)
• IS-82 Hypoxia induces expression of COX-2 through the homeodomain transcription factor CDX2 and orphan nuclear receptor SHP in human endometriotic stromal cells(Group10 Reproduction4,International Session)
• ISO-12 The pharmacological NF-κB inhibitor BAY11-7085 suppresses the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-lin TNF-α-stimulated human endometriotic stromal cells(Group3 Reproduction,International Session : Ora
• Correction of Critical Dimension Uniformity on a Wafer by Controlling Back-Surface Transmittance Distribution of a Photomask
• Reduction of Viewing-Angle Dependent Color Shift in a Reflective Type Cholesteric Liquid Crystal Color Filter
• Effects of Grape Seed Proanthocyanidin on 5-Hydroxytryptamine3 Receptors in NCB-20 Neuroblastoma Cells
• Prediction of the Transition Criterion to Annular Flow in Two-Phase Flow Pattern of Refrigerants
• CYP2D6^*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population
• Systemic Plasmacytosis : A Case which Improved with Melphalan
• Intense accumulation of ^F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors
• The histologic and biomechanical comparative analysis of bone ingrowth effect of porous hydroxyapatite impregnated bone cement implanted in distal femur of rabbit
• Frequency Detuning and Stabilization of a Diode Laser Using the Zeeman Shift of the Saturated Absorption Signal of Rubidium Atoms
• P1-IS-16 A case of clear cell cancer of cervix of 6-year-old girl diagnosed by shedding mass without in utero DES exposure
• IS-68 Doppler assessment of fetal aortic isthmus flow in twin growth discordance(Group9 Perinatology3,International Session)
• OPTIMAL CONTROL PROBLEM FOR THE NONLINEAR HYPERBOLIC SYSTEMS (Nonlinear Analysis and Convex Analysis)
• IV D3 Mutations of voltage-gated sodium channel alpha 1 subunit(SCN1A)gene in febrile seizures
• Usefulness of Computed Tomographic Pulmonary Angiography in the Risk Stratification of Acute Pulmonary Thromboembolism : Comparison With Cardiac Biomarkers
• Myocardial Infarction With Moyamoya Disease and Pituitary Gigantism in a Young Female Patient
• Adaptation of Aspergillus niger to Multiple Agents Whose Action Mechanisms are Different

もっと見る 閉じる

スポンサーリンク