Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats(Pharmacology)
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概要
- 論文の詳細を見る
The preventive effect of Anemarrhena asphodeloides BUNGE (Liliaceae), a traditional Chinese medicine, on ischemia-reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2h and reperfusion was continued for 22h. Water extract of Anemarrhena asphodeloides (WEAA) was orally administered promptly prior to and 2h after reperfusion. Total infarct volume and edema in the ipsilateral hemispheres of ischemia-reperfusion rats were significantly reduced by treatment with WEAA in a dose-dependent manner (p<0.05). The therapeutic time window of WEAA was 3h in this ischemia-reperfusion rat model. WEAA also significantly inhibited increased neutrophil infiltration of ischemic brain tissue as estimated by myeloperoxidase (MPO) activity and immunohistochemical analysis. MPO-positive cells were markedly reduced by WEAA administration in striatal and cortical areas. These findings suggest that WEAA plays a crucial protective role in ischemia-induced brain injury, and suggest that WEAA could serve as a lead medicinal herb for the development of neuroprotective agents following transient focal ischemic brain injury.
- 社団法人日本薬学会の論文
- 2007-01-01
著者
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KIM Sun
Graduate School of East-West Medicine, Kyung Hee University
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Kim Ki
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Ryu Jong
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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JUNG Ji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Ryu Jong
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Lee S‐y
Kt&g Central Research Institute
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PARK Ji
Graduate School of East-West Medical Science, Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Jung Ji
Department Of Herbal Medicinal Resource College Of Health And Welfare Daegu Haany University
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Ryu Jong
Department Of Oriental Pharmaceutical Science Kyunghee University
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Kim Yong-won
Department Of Oriental Pharmaceutical Science And Kyung Hee East-west Pharmaceutical Research Instit
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Park Ji
Graduate School Of East-west Medical Science Kyung Hee University
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Lee Sun-young
Department Of Oriental Pharmaceutical Science And Kyung Hee East-west Pharmaceutical Research Instit
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Oh Jin
Department Of Urology Seoul National University College Of Medicine
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HYUN Seung
Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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OH Hye
Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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PARK Chan
Department of Anatomy, College of Medicine, Kyung Hee University
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LEE Sun-Young
Graduate School of East-West Medical Science, Kyung Hee University
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Jung Ji
Department Of Genetic Epidemiology Snp Genetics Inc.
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Kim Ki
Department Of Forest Products College Of Forest Science Kookmin University
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Lee S‐m
Kyung‐hee Univ. Seoul Kor
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Oh Hye
Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University
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Oh Jin
Department Of Mechanical Engineering Pohang University Of Science And Technology
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Oh Jin
Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Hyun Seung
Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University
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Park Chan
Department Of Anatomy College Of Medicine Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science
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Oh Jin
Department Of Internal Medicine Dongguk University Ilsan Hospital
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JUNG Ji
Department of Anatomy, College of Medicine, Hallym University
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Oh Jin
Department of Advanced Materials Engineering, Yonsei University, Seoul 120-749, Korea
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