The Effects of PVA/Chitosan/Fibroin (PCF)-Blended Spongy Sheets on Wound Heailng in Rats

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概要

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• The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2×2 cm in size. The wound was convered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12 d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge≥Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

• 社団法人日本薬学会の論文
• 2000-10-01

著者

• KIM Sun

  Graduate School of East-West Medicine, Kyung Hee University

• Yeo Joo

  Department Of Sericulture And Entomology National Institute Of Agriculture And Technology

• Yeo Joo

  韓国

• Oh Young

  Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

• LEE Kwang

  Department of Sericulture and Entomology, National Institute of Agriculture and Technology

• KIM Ho

  Graduate School of East-West Medical Science, Kyunghee University

• KIM Ae-Jeong

  Department of Food & Nutrition, Hejeon College

• Kim Ae-jeong

  Department Of Food & Nutrition Hejeon College

• Kim Ae-jeong

  韓国

• Oh Young

  Department Of Anesthesiology And Pain Medicine Yonsei University College Of Medicine:anesthesia And

• Lee Kwang

  Department Of Sericulture And Entomology National Institute Of Agriculture And Technology

• Kim Ho

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Ho

  Graduate School Of East-west Medical Science Kyunghee University

• Oh Young

  Department Of Diagnostic Pathology Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kim Sun

  Graduate School Of East-west Medical Science Kyunghee University

• Yeo Joo

  Department Of Chemical Engineering Seoul National University

• Lee Kwang

  Department Of Bioengineering Yonsei University

• Kim Sun

  Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky

• Kim Sun

  Graduate School Of East-west Medical Science

• Lee Kwang

  Department of Advanced Technology Fusion (DATF), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea

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